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A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Related publications (42)

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Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature

Theofanis Stampoultzis

Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based fu ...

EPFL2024

Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications.

Sandrine Gerber, François Rémi Pierre Noverraz, Alireza Kavand

With its exceptional biocompatibility, alginate emerged as a highly promising biomaterial for a large range of applications in regenerative medicine. Whether in the form of microparticles, injectable hydrogels, rigid scaffolds, or bioinks, alginate provide ...

2024

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The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patte ...

2023

Single fraction and hypofractionated radiosurgery for perioptic meningiomas-tumor control and visual outcomes: a systematic review and meta-analysis

Constantin Tuleasca

Perioptic meningiomas, defined as those that are less than 3 mm from the optic apparatus, are challenging to treat with stereotactic radiosurgery (SRS). Tumor control must be weighed against the risk of radiation-induced optic neuropathy (RION), as both tu ...

New York2023

Diamond Open Access is a scholarly publishing model characterized by journals and platforms that do not impose fees nor on authors neither on readers. These journals typically operate as community-driven, academically-led, and academically-owned initiative ...

2023

Cybersickness still poses a significant challenge to the widespread usage of virtual reality, leading to different levels of dis- comfort and potentially breaking the immersive experience. Researchers have attempted to discover the possible fundamental cau ...

2022

monOApoly: a board game about Open Access

Lorenza Salvatori, Manon Velasco

How not to get lost in the quest to publish an Open Access article? This game focuses on how a researcher can make their publication compliant with the Open Access requirements of their institution and funders. To be compliant today, a researcher should tr ...

2022

Thoughts on cartilage tissue engineering: A 21st century perspective

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the ad ...

2021

Hybrid hydrogels for load-bearing implants

Céline Samira Wyss

Load-bearing tissues such as articular cartilage or meniscus are not infallible. They might fail due to trauma, over-solicitations, or diseases, which could subsequently alter the mobility of the patient. Repairing these damaged tissues in a minimally inva ...

EPFL2021

Wearable Sensor-Based Real-Time Gait Detection: A Systematic Review

Auke Ijspeert, Grégoire Courtine, Joachim von Zitzewitz, Miroslav Caban, Hari Prasanth, Urs Keller

Gait analysis has traditionally been carried out in a laboratory environment using expensive equipment, but, recently, reliable, affordable, and wearable sensors have enabled integration into clinical applications as well as use during activities of daily ...

2021