Publication
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
Related publications (43)
Extensive programmed centriole elimination unveiled in C. elegans embryos
Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...
AMER ASSOC ADVANCEMENT SCIENCE2023Dataset for "Extensive programmed centriole elimination unveiled in C. elegans embryos."
Full dataset related to the publication "Extensive programmed centriole elimination unveiled in C. elegans embryos." ...
EPFL Infoscience2023Toxic Effects of Koumine on the Early-Life Development Stage of Zebrafish
Koumine is one of the most abundant alkaloids found in Gelsemium elegans, and it has a wide range of pharmacological effects including antitumor, anti-inflammatory, analgesic treatment effects, and antianxiety. However, its high toxicity and unclear mechan ...
Basel2023Dissecting centriole fate in C. elegans development
The presence of centrioles is critical for fundamental cell and developmental processes, including polarity, migration and division. Although centrioles are present in most proliferating cells, they are thought to vanish after cell cycle exit in some diffe ...
EPFL2022Unequal cleavage of the C. elegans zygote ensures robust embryogenesis
Asymmetric cell divisions play key roles in generating cellular diversity during embryogenesis, and in tissue homeostasis during postembryonic life. Particular asymmetric cell divisions producing differentially sized daughter cells were described in many s ...
EPFL2020Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models
Matthias Lütolf, Stefano Davide Vianello
Research in developmental biology has been recently enriched by a multitude of in vitro models recapitulating key milestones of mammalian embryogenesis. These models obviate the challenge posed by the inaccessibility of implanted embryos, multiply experime ...
2019Enhancing developmental rate and quality of mouse single blastomeres into blastocysts using a microplatform
Philippe Renaud, Leila Montazeri, Hanie Kavand
The present work reports the beneficial effects of using a microplatform on the development of mouse single blastomeres (SBs) to the blastocyst stage. Development of blastocysts from SBs separated from two‐ and four‐cell stage embryos (two‐ and four‐cell S ...
20188-Channel Single Embryo Pipette For Accurate C-Elegans Bioassays
Martinus Gijs, Thomas Lehnert, Li Dong, Jingwei Zhang
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism for addressing fundamental biological questions related to human disease and aging. Accurate control of the number of worms is a primary step for quantitative biological or bioch ...
IEEE2018Role of Cnot6l in maternal mRNA turnover
Removal of poly(A) tail is an important mechanism controlling eukaryotic mRNA turnover. The major eukaryotic deadenylase complex CCR4-NOT contains two deadenylase components, CCR4 and CAF1, for which mammalian CCR4 is encoded by Cnot6 or Cnot6l paralogs. W ...
Rockefeller University Press2018Molecular Criteria for Defining the Naive Human Pluripotent State
Didier Trono, Evaristo Jose Planet Letschert, Julien Léonard Duc, Marc Samuel Friedli, Alexandra Iouranova, Michaël Imbeault, Julien Paul André Pontis, Haoyi Wang
Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive ...
Cell Press2016