The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach
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Although left ventricular end-systolic elastance (E-es) serves as a major index of cardiac contractility, a widely-accepted noninvasive estimation of E-es does not exist. To overcome this limitation, we developed a two-step inverse method that allows for i ...
Aim: The investigation of the association between total arterial compliance (C-T)-estimated by a novel technique-with left ventricular mass (LVM) and hypertrophy (LVH). Our hypothesis was that C-T may be better related to LVM compared to the gold-standard ...
Taylor & Francis Inc2017
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The evaluation of cardiac contractility by the assessment of the ventricular systolic elastance function is clinically challenging and cannot be easily obtained at the bedside. In this work, we present a framework characterizing left ventricular systolic f ...
2020
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Diastolic dysfunction (DD) is a major component of heart failure with preserved ejection fraction (HFpEF). Accordingly. a profound understanding of the underlying biomechanical mechanisms involved in DD is needed to elucidate all aspects of HFpEF. In this ...
AMER PHYSIOLOGICAL SOC2020
The monitoring of central hemodynamic parameters such as cardiac output (CO) and pulmonary artery pressure (PAP) is of paramount clinical importance to assess the health status of the cardiovascular system. However, their measurement requires the insertion ...
EPFL2017
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During aging, systolic blood pressure continuously increases over time, whereas diastolic pressure first increases and then slightly decreases after middle age. These pressure changes are usually explained by changes of the arterial system alone (increase ...
Public Library of Science2016
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In this study, an image-based morphometry toolset quantifying geometric descriptors of the left ventricle, aorta and their coupling is applied to investigate whether morphological information can differentiate between subjects affected by diastolic dysfunc ...
Elsevier2017
Background-Congenital heart disease is the most common type of birth defect, affecting approximate to 2% of the population. Malformations involving the cardiac outflow tract and semilunar valves account for >50% of these cases predominantly because of a bi ...
Wiley-Blackwell2016
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Cardiac and aortic characteristics are crucial for cardiovascular disease detection. However, noninvasive estimation of aortic hemodynamics and cardiac contractility is still challenging. This paper investigated the potential of estimating aortic systolic ...
2020
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We construct an idealized computational model of the left human heart for the study of the blood flow dynamics in the left atrium and ventricle. We solve the Navier-Stokes equations in the ALE formulation and we prescribe the left heart wall displacement b ...
