Publication

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Related publications (53)

Research on microglia in Down syndrome (DS) has shown that microglial activation, increased inflammatory gene expression, and oxidative stress occur at different ages in DS brains. However, most studies resulted in simplistic definitions of microglia as qu ...

Basel2024

The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...

EPFL2023

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Valentina Marie Paggi

The peripheral nervous system (PNS) regulates the exchange of sensory information andmotor commands between the body and the central nervous system. Further, through theautonomic nervous system, the PNS plays a pivotal role in controlling vital physiologic ...

EPFL2023

Fractal analysis in the quantification of medical imaging associated with multiple sclerosis pathology

Maria-Alexandra Paun

Backgrounds: Multiple sclerosis (MS) is an inveterate phlogistic situation characterized by focal and vaguely diffusive de-myelination and neurodegeneration, in the sphere of central nervous system (CNS). The brain's chronic inflammatory reaction includes ...

IMR PRESS2022

Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper

Traian Popa

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...

ELSEVIER IRELAND LTD2022

Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis

Patrick Aebischer, Bernard Schneider, Nathalie Marie Géraldine Bernard, Cylia Cloé Rochat

In amyotrophic lateral sclerosis (ALS) caused by SOD1 gene mutations, both cell-autonomous and noncell-autonomous mechanisms lead to the selective degeneration of motoneurons (MN). Here, we evaluate the therapeutic potential of gene therapy targeting mutat ...

WILEY2022

Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as "reactive astrogliosis." Diversity in ...

2021

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Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts

Jean-Philippe Thiran, Gabriel Girard, David Paul Roger Romascano, Alessandro Daducci, Cristina Granziera, Muhamed Barakovic, Maxime Descoteaux, Giorgio Innocenti

In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However ...

2021

Structural architecture of the Neuronal-Glial-Vascular system

Eleftherios Zisis

Brain functionality relies on the neuronal-glial-vascular (NGV) ensemble for energy support. However, the details of the complex biological mechanisms involved in these processes and the microscopic interactions between these three components are not yet f ...

EPFL2021

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