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Accurate Diagnosis of Cortical and Infratentorial Lesions in Multiple Sclerosis Using Accelerated Fluid and White Matter Suppression Imaging

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Physics of magnetic resonance imaging

The physics of magnetic resonance imaging (MRI) concerns fundamental physical considerations of MRI techniques and technological aspects of MRI devices. MRI is a medical imaging technique mostly used in radiology and nuclear medicine in order to investigate the anatomy and physiology of the body, and to detect pathologies including tumors, inflammation, neurological conditions such as stroke, disorders of muscles and joints, and abnormalities in the heart and blood vessels among others.

Medical image computing

Medical image computing (MIC) is an interdisciplinary field at the intersection of computer science, information engineering, electrical engineering, physics, mathematics and medicine. This field develops computational and mathematical methods for solving problems pertaining to medical images and their use for biomedical research and clinical care. The main goal of MIC is to extract clinically relevant information or knowledge from medical images.

Sign test

The sign test is a statistical method to test for consistent differences between pairs of observations, such as the weight of subjects before and after treatment. Given pairs of observations (such as weight pre- and post-treatment) for each subject, the sign test determines if one member of the pair (such as pre-treatment) tends to be greater than (or less than) the other member of the pair (such as post-treatment). The paired observations may be designated x and y.

Krippendorff's alpha

Krippendorff's alpha coefficient, named after academic Klaus Krippendorff, is a statistical measure of the agreement achieved when coding a set of units of analysis. Since the 1970s, alpha has been used in content analysis where textual units are categorized by trained readers, in counseling and survey research where experts code open-ended interview data into analyzable terms, in psychological testing where alternative tests of the same phenomena need to be compared, or in observational studies where unstructured happenings are recorded for subsequent analysis.