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A digital bridge between brain and spinal cord restores walking after paralysis
Related publications (33)
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Arwen Blanche Giraud
Task-based functional magnetic resonance imaging bears great potential to understand how our brain reacts to various types of stimulation; however, this is often achieved without considering the dynamic facet of functional processing, and analytical output ...
2019Neuromodulation in the restoration of function after spinal cord injury
Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as a treatment approach in several neurological disorders, including deep brain stimulation for Parkinson's disease and epidural spinal stimulation for chroni ...
2018Cortico-reticulo-spinal circuits mediate functional recovery after spinal cord contusion
After a spinal cord injury (SCI), only half of affected individuals regain voluntary control of leg movements below the level of the lesion. Anatomical, electrophysiological and imaging data revealed that even the most severe forms of SCI usually spare a s ...
EPFL2017Brain-Controlled Neuroprosthetic Therapies And Mechanisms Of Recovery After Spinal Cord Injury
Spinal cord injury (SCI) is the second leading cause of paralysis, which induces abrupt impairments with devastating consequences for the quality of life of patients. Despite significant progress in SCI treatment through neurorehabilitation training and sp ...
EPFL2017Brain-controlled neuroprosthetic interventions to restore locomotion after contusion spinal cord injury in the rat
Spinal cord injury (SCI), second only to stroke, is the leading cause of paralysis. Therapies based on electrical stimulation of the spinal cord and other locomotor areas of the Nervous System improve motor control in people with neurotrauma. Neuromodulati ...
EPFL2017A brain-spine interface alleviating gait deficits after spinal cord injury in primates
Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Tomislav Milekovic, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, David Allenson Borton, Simone Ellen Joze Duis, Elodie Rey
Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...
Nature Publishing Group2016The role of MgB12H12 in the hydrogen desorption process of Mg(BH4)(2)
The presence of MgB12H12 has often been considered as the major obstacle for the reversible hydrogen storage in Mg(BH4)(2). This communication provides evidence that the MgB12H12 phase (or B12H12 monomer) does not exist in the decomposition products ...
Royal Soc Chemistry2015Neurorehabilitation and neuroprosthetic technologies to regain motor function following spinal cord injury
Spinal cord injury (SCI) leads to a range of disabilities, including locomotor impairments that seriously diminish the patients’ quality of life. Strategies to promote functional recovery after severe SCI will undoubtedly include approaches to regenerate i ...
ETH Zurich2014Corticospinal neuroprostheses to restore locomotion after spinal cord injury
José del Rocio Millán Ruiz, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Marco Bonizzato, Janine Beauparlant, David Allenson Borton
In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...
Elsevier2014MUNDUS project: MUltimodal Neuroprosthesis for daily Upper limb Support
Silvestro Micera, Andrea Crema, Claudia Casellato
Background: MUNDUS is an assistive framework for recovering direct interaction capability of severely motor impaired people based on arm reaching and hand functions. It aims at achieving personalization, modularity and maximization of the user's direct inv ...
Biomed Central Ltd2013