Friedreich's ataxiaFriedreich's ataxia (FRDA or FA) is an autosomal-recessive genetic disease that causes difficulty walking, a loss of coordination in the arms and legs, and impaired speech that worsens over time. Symptoms generally start between 5 and 20 years of age. Many develop hypertrophic cardiomyopathy and require a mobility aid such as a cane, walker, or wheelchair in their teens. As the disease progresses, some affected people lose their sight and hearing. Other complications may include scoliosis and diabetes mellitus.
Neural oscillationNeural oscillations, or brainwaves, are rhythmic or repetitive patterns of neural activity in the central nervous system. Neural tissue can generate oscillatory activity in many ways, driven either by mechanisms within individual neurons or by interactions between neurons. In individual neurons, oscillations can appear either as oscillations in membrane potential or as rhythmic patterns of action potentials, which then produce oscillatory activation of post-synaptic neurons.
Latin alphabetThe Latin alphabet, also known as the Roman alphabet, is the collection of letters originally used by the ancient Romans to write the Latin language. Largely unaltered with the exception of extensions (such as diacritics), it forms the Latin script that is used to write many modern European languages, including English. With modifications, it is also used for other alphabets, such as the Vietnamese alphabet. Its modern repertoire is standardised as the ISO basic Latin alphabet.
Latin scriptThe Latin script, also known as the Roman script, is an alphabetic writing system based on the letters of the classical Latin alphabet, derived from a form of the Greek alphabet which was in use in the ancient Greek city of Cumae, in southern Italy (Magna Graecia). The Greek alphabet was adopted by the Etruscans, and subsequently their alphabet was adopted by the Romans. Several Latin-script alphabets exist, which differ in graphemes, collation and phonetic values from the classical Latin alphabet.
HypertoniaHypertonia is a term sometimes used synonymously with spasticity and rigidity in the literature surrounding damage to the central nervous system, namely upper motor neuron lesions. Impaired ability of damaged motor neurons to regulate descending pathways gives rise to disordered spinal reflexes, increased excitability of muscle spindles, and decreased synaptic inhibition. These consequences result in abnormally increased muscle tone of symptomatic muscles.
