Publication

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Abstract

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative questions are posed, they are mostly evaluated on a small, regular grid of parameter values, thus greatly reducing the wealth of admissible possibilities. The main obstacle to the use of computational models is their very high computational complexity, which prevents testing a large number of parameter values. Here, we show that it is possible to train a regressor that predicts the firing rate of nerve fibers stimulated according to a given multipolar electrical stimulation protocol, and show its possible application to a simplified model of optic nerve stimulation. Our results show that it is possible to build a very accurate surrogate model of nerve fiber stimulation, and that its reduced computational cost allows to perform automatic optimization of multipolar electrical stimulation protocols via evolutionary heuristics.

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Ontological neighbourhood
Related concepts (32)
Nerve
A nerve is an enclosed, cable-like bundle of nerve fibers (called axons) in the peripheral nervous system. Axons transmit electrical impulses. Nerves have historically been considered the basic units of the peripheral nervous system. A nerve provides a common pathway for the electrochemical nerve impulses called action potentials that are transmitted along each of the axons to peripheral organs or, in the case of sensory nerves, from the periphery back to the central nervous system.
Autonomic nervous system
The autonomic nervous system (ANS), formerly referred to as the vegetative nervous system, is a division of the nervous system that supplies internal organs, smooth muscle and glands. The autonomic nervous system is a control system that acts largely unconsciously and regulates bodily functions, such as the heart rate, its force of contraction, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response.
Vagus nerve
The vagus nerve, also known as the tenth cranial nerve, cranial nerve X, or simply CN X, is a cranial nerve that carries sensory fibers that create a pathway that interfaces with the parasympathetic control of the heart, lungs, and digestive tract. It comprises two nerves—the left and right vagus nerves—but they are typically referred to collectively as a single subsystem. The vagus is the longest nerve of the autonomic nervous system in the human body and comprises both sensory and motor fibers.
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