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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

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Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

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A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation

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Type I Interferon Signaling Prevents IL-1 beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

Self-priming determines high type I IFN production by plasmacytoid dendritic cells