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Identifying genetic and dietary modulators of metabolic disorders using systems genetics
Related publications (116)
Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster
Work on Drosophila melanogaster paved the way to our current understanding of modern genetics. Since then, this model organism has contributed greatly to various fields such as neurobiology, development, and immunology. The discovery and analysis of the va ...
EPFL2019Large-scale variational inference for Bayesian joint regression modelling of high-dimensional genetic data
Genetic association studies have become increasingly important in understanding the molecular bases of complex human traits. The specific analysis of intermediate molecular traits, via quantitative trait locus (QTL) studies, has recently received much atte ...
EPFL2019Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
Johan Auwerx, Evan Graehl Williams
The BXD family has become one of the preeminent genetic reference populations to understand the genetic and environmental control of phenotypic variation. Here we evaluate the responses to different levels of fat in the diet using both chow diet (CD, 13-18 ...
PUBLIC LIBRARY SCIENCE2019A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals
Jacques Fellay, Christian Hammer, Flavia Aurelia Shoko Hodel, Petar Scepanovic
Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...
2019Systems genetics approaches to probe gene function
Genes are the functional units of heredity. However, the functions of many genes remain unknown, which impedes the understanding of the underlying mechanism of complex traits and diseases. Systems genetics approaches try to understand the complexity underl ...
EPFL2019Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
Patrick Descombes, Sylviane Métairon, Jörg Hager, Hélène Ruffieux, Nele Gheldof
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains ...
Springer2019Analysis of Inherited Optic Neuropathies
Background Inherited optic neuropathies (IONs) cover a spectrum of clinically and genetically heterogenic conditions. Genetic evaluation of patients with IONs may enable their better clinico-diagnostic assessment and management of the disease. The aim of t ...
2019Sex-dependent and sex-independent regulatory systems of size variation in natural populations
Bart Deplancke, Vincent Roland Julien Gardeux, Ernst Hafen
Size of organs/organisms is a polygenic trait. Many of the growth-regulatory genes constitute conserved growth signaling pathways. However, how these multiple genes are orchestrated at the systems level to attain the natural variation in size including sex ...
WILEY2019Clinical and Genetic Findings of Autosomal Recessive Bestrophinopathy (ARB)
Mutations in BEST1 cause several phenotypes including autosomal dominant (AD) Best vitelliform macular dystrophy type 2 (BVMD), AD vitreo-retino-choroidopathy (ADVIRC), and retinitis pigmentosa-50 (RP50). A rare subtype of Bestrophinopathy exists with bial ...
2019Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018