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Aptamer Renaissance for Neurochemical Biosensing

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Decoupling of brain function from structure reveals regional behavioral specialization in humans

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti

The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected areas can be expe ...

2019

Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by (13)C Magnetic Resonance Spectroscopy

Rolf Gruetter, João Miguel das Neves Duarte, Sarah Catherine Sonnay, Freya-Merret Girault

Type 2 diabetes (T2D) is associated with deterioration of brain structure and function. Here, we tested the hypothesis that T2D induces a reorganization of the brain metabolic networks that support brain function. For that, alterations of neuronal and glia ...

2019

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Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brains remain unclear. Here we report that ketones can increase ...

2018

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The combination of 3D echo planar imaging (3D-EPI) with a 2D-CAIPIRINHA undersampling scheme provides high flexibility in the optimization for spatial or temporal resolution. This flexibility can be increased further with the addition of a cylindrical exci ...

2018

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The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure ...

FRONTIERS MEDIA SA2018

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Handbook of Brain Microcircuits, Section 1: Neocortex, Chapter 3, Updated and revised, the second edition of Handbook of Brain Microcircuits covers the functional organization of 50 brain regions. This now-classic text uses an interdisciplinary approach to ...

Oxford University Press2018

Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex

Gregor Rainer, Laura Lozano Montes, Nan Zhao

Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...

2018

Case-Control Discrimination Through Effective Brain Connectivity

Luca Dodero

Functional and structural connectivity convey different information about the brain. The integration of these different approaches is receiving growing attention from the research community, as it can shed new light on brain functions. This manuscript prop ...

Ieee2017

Comments and General Discussion on “The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution”

Sean Lewis Hill, Idan Segev

This article gathers together different opinions on the current status and future directions of the study of the brain, taking as a working document the article “The anatomical problem posed by brain complexity and size: a potential solution” http://journa ...

Frontiers Research Foundation2016

Global tractography with embedded anatomical priors and microstructure information for quantitative connectomics

Alia Lemkaddem

Over the last decades new technologies have shed the light on an improved understanding of brain structure and function. Recently, an imaging modality referred to as diffusion Magnetic Resonance Imaging (dMRI) has emerged. By exploiting the natural motion ...

EPFL2015