Publication
Multimodal transcriptomic atlases of mouse spinal cord injury
Related publications (52)
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The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...
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Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...
EPFL2023Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart
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Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans. Transcriptomics analysis has contributed to dissect underlying signa ...
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SiliFish is an open-source desktop application tomodel and study zebrafish swimming. Here, we explain how to define the general parameters of the model, define cell populations, place them within the spinal cord, and define their projections. We explain ho ...
Amsterdam2023Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons
Grégoire Courtine, Jordan Squair, Claudia Kathe, Yi Ding
After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...
NATURE PORTFOLIO2022Towards elucidating the structural and cellular determinants of a-synuclein seeding and toxicity
Although it has been nearly two and half decades since the discovery of alpha-synuclein (aSyn) as the major component of Lewy bodies (LBs), our understanding of the involvement of different aSyn species, their seeding, spreading and toxicity in Parkinson's ...
EPFL2022Natural and targeted circuit reorganization after spinal cord injury
Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Claudia Kathe, Matthieu Pierre Gautier, Thomas Haynes Hutson
The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. A spina ...
NATURE PORTFOLIO2022Prevention of the foreign body response to implantable medical devices by inflammasome inhibition
Fibrotic scarring secondary to the foreign body reaction (FBR) generates a physical barrier obstructing the functional interaction of implantable medical devices with the host tissue. The mechanistic basis of the FBR is poorly understood, restricting the c ...
NATL ACAD SCIENCES2022