Publication
Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Related publications (37)
Duality in the Mechanism of Hexagonal ZnO/CuxO Nanowires Inducing Sulfamethazine Degradation under Solar or Visible Light
César Pulgarin, Juan Kiwi, Sami Rtimi, Jiajie Yu
This study presents the first evidence for the photocatalytic performance of ZnO/CuxO hexagonal nanowires leading to sulfamethazine (SMT) degradation. The chemical composition of the nanowires was determined by X-ray fluorescence (XRF). The sample with the ...
2019Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein
Marcela Rincón-Restrepo, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Clara Galan Navarro, Stefan Kunz
Lassa virus (LASV) causes severe hemorrhagic fever with high mortality, yet no vaccine currently exists. Antibodies targeting viral attachment proteins are crucial for protection against many viral infections. However, the envelope glycoprotein (GP) 1 of L ...
Academic Press Inc Elsevier Science2017Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles
Analyzing surface epitopes of single HIV particles holds great potential for the development of vaccine candidates. However, existing technologies do not allow corresponding screens at high throughput. We present here a single-virus droplet-based microflui ...
2017Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins
Vaccines currently represent one of the most effective means to control and prevent infectious diseases affecting humans and animals and have dramatically improved public health, quality of life, and life expectancy. Over the last years several conceptual ...
EPFL2017Plasmonic photo-current in freestanding monolayered gold nanoparticle membranes
We report on photo-current generation in freestanding monolayered gold nanoparticle membranes excited by using a focused laser beam. The absence of a substrate leads to a 50% increase of the photo-current at the surface plasmon resonance. This current is a ...
Royal Society of Chemistry2016Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces
Paolo De Los Rios, Giuseppe Foffi, Francesco Piazza
In this paper we introduce a fully flexible coarse-grained model of immunoglobulin G (IgG) antibodies parametrized directly on cryo-EM data and simulate the binding dynamics of many IgGs to antigens adsorbed on a surface at increasing densities. Moreover, ...
Public Library Science2016A novel encapsulation device for peripheral implantation of antibody-secreting cells
Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly. As populations are aging in most parts of the world, the number of people with Alzheimer’s disease is expected to dramatically increase. This devastating neurodegenerative diso ...
EPFL2013Nucleation and Island Growth of Alkanethiolate Ligand Domains on Gold Nanoparticles
The metal oxide cluster alpha-AIW(11)O(39)(9-) (1), readily imaged by cryogenic transmission electron microscopy (cryo-TEM), is used as a diagnostic protecting anion to investigate the self-assembly of alkanethiolate monolayers on electrostatically stabili ...
American Chemical Society2012Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells
Florian Maria Wurm, Yury Tsybin, Lucia Baldi Unser, Sophie Nallet, Luca Fornelli, Simone Schmitt, Julien Parra
In this study, a recombinant monoclonal IgG antibody was produced by transient gene expression (TGE) in suspension-adapted HEK-293E cells. The objective of the study was to determine the variation in recombinant IgG yield and glycosylation in ten independe ...
Elsevier2012Flexible antibodies with nonprotein hinges
There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a. novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more f ...
2011