Publication
Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles
Related publications (36)
Peptide-based virucidal drugs
Before the COVID-19 pandemic, viruses were not a major priority for the scientific community. Today, many events have changed the world and the importance of studying viruses, vaccines, and antiviral drugs is fully appreciated. The development of effective ...
EPFL2024Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort
Jacques Fellay, Zhi Ming Xu, Dylan Lawless, Thomas Junier
Background. Respiratory syncytial virus (RSV) is associated with acute respiratory infection. We sought to identify RSV variants associated with prolonged infection. Methods. Among healthy term infants we identified those with prolonged RSV infection and c ...
OXFORD UNIV PRESS INC2023Multivalent Virucidal Antivirals: Synthesis, Mechanisms of Action, and Immune-stimulating Effects
Viruses initiate invasion by binding to cell surface glycoproteins. Materials mimicking the carbohydrate motifs of these glycoproteins, such as heparan sulfate (HS) and sialic acid (SA) can block viral attachment and inhibit the infection. Multivalent disp ...
EPFL2023Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism
Francesco Stellacci, Matteo Gasbarri, Valeria Cagno
Heparin has been known to be a broad-spectrum inhibitor of viral infection for almost 70 years, and it has been used as a medication for almost 90 years due to its anticoagulant effect. This nontoxic biocompatible polymer efficiently binds to many types of ...
AMER CHEMICAL SOC2022High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Gerardo Turcatti, Fabien Kuttler
Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- ...
2022Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Gerardo Turcatti, Fabien Kuttler, Michael Bauer, Liliane Yang
Endemic human coronaviruses (hCoVs) 229E and OC43 cause respiratory disease with recurrent infections, while severe acute respiratory syndrome (SARS)-CoV-2 spreads across the world with impact on health and societies. Here, we report an image-based multicy ...
2022Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Gerardo Turcatti, Marc Chambon, Damiano Banfi, Jonathan Patrice Vesin
Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number of live ...
AMER SOC MICROBIOLOGY2021Novel broad-spectrum virucidal antivirals
The current COVID-19 pandemic has showed the threats that viruses can cause to the whole world. Over 200 million infections and over 4.5 million deaths and enormous socio-economic impact were the output of the emergence of a single new pathogen: SARS-CoV-2 ...
EPFL2021Advances in the development of entry inhibitors for sialic-acid-targeting viruses
Francesco Stellacci, Matteo Gasbarri, Özgün Kocabiyik
Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional stra ...
ELSEVIER SCI LTD2021Modified cyclodextrins as broad-spectrum antivirals
Francesco Stellacci, Natalia Gasilova, Matteo Gasbarri, Valeria Cagno, Samuel Thomas Jones, Matej Janecek
Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...
AMER ASSOC ADVANCEMENT SCIENCE2020