Reconstruction and analysis of genome-scale metabolic networks in single organisms and microbial communities
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Metabolic Engineering is fostered by an increasing effort and progress in the collection of large and accurate 'omics' datasets. The abundance of available measurements and advances in measurement techniques only alleviate to a certain extent the uncertai ...
In metabolic modeling, experimental data is used to constrain the solution space of allowable flux distributions to biologically feasible phenotypes. This makes metabolic modeling a powerful tool for integrating information from different experimental sour ...
Proteins are a ubiquitous and indispensable element for every living organism, from simple bacteria to mammals. Already in the simplest organisms, there exist some thousands of different protein species that take up a great variety of structures, and thus ...
Genome-scale metabolic reconstructions capture the known metabolic capabilities of organisms and their analysis have provided many insights into complex biochemical networks. However, this approach relies on a database of known biochemical reactions and he ...
Cellular metabolism is the driving force of all living cells and organisms. Numerous research projects undertaken over the past century have attempted to decipher the function and operating principles of metabolism with varying degrees of success. A wide s ...
Although the prevalence of main idiopathic forms of inflammatory bowel disease (IBD) has risen considerably over the last decades, their clinical features do not allow accurate prediction of prognosis, likelihood of disease progression, or response to spec ...
Model organisms are an important tool for the development and validation of analytical approaches for proteomics and for the study of basic mechanisms of biological processes. The Initiative on Model Organism Proteomics (iMOP) organized a session during th ...
Genome-scale metabolic reconstructions (GSMRs) are valuable resources in the analysis and understanding of cellular metabolism. They are based on genome sequence and annotation, and they are to develop bottom-up mathematical models of metabolic networks. T ...
Advancements in high-throughput technologies to measure increasingly complex biological phenomena at the genomic level are rapidly changing the face of biological research from single-gene single-protein experimental approach to studying the behaviour of a ...
Genome-scale metabolic reconstructions have become indispensable tools for understanding and investigation of the metabolism of any organism in this post-genomic era. However, there are still knowledge gaps in our understanding of the metabolism of even th ...