Publication
S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells
Related publications (88)
Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein
Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the end ...
PUBLIC LIBRARY SCIENCE2023Dynamics of CLIMP-63 S-acylation control ER morphology
Vassily Hatzimanikatis, Françoise Gisou van der Goot Grunberg, Graham Knott, Kathryn Hess Bellwald, Laurence Gouzi Abrami, Luciano Andres Abriata, Béatrice Kunz, Sylvia Ho, Patrick Alain Sandoz, Catherine Maclachlan, Robin Alexander Denhardt-Eriksson, Gard Spreemann
A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...
NATURE PORTFOLIO2023Inhibitors of acyl protein thioesterases against microbial infections
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Valeria Cagno
The present invention relates inhibitors of acyl protein thioesterases and method of preparation thereof. It also relates to the use of inhibitors of acyl protein thioesterases in the treatment and/or prevention of a microbial infection such as viral or ba ...
2023Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3
Giovanni D'Angelo, Laura Capolupo, Anthony Vocat, Riccardo Rizzo
Glycosphingolipids are important components of the plasma membrane where they modulate the activities of membrane proteins including signalling receptors. Glycosphingolipid synthesis relies on competing reactions catalysed by Golgi-resident enzymes during ...
WILEY2021Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Laurence Gouzi Abrami, Florence Pojer, Sylvia Ho, Francisco De Magalhães Sarmento R De Mesquita, Patrick Alain Sandoz, Martina Audagnotto, Giulia Fonti, Muhammad Umair Anwar
Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. Many biochemica ...
NATURE RESEARCH2021Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications
Françoise Gisou van der Goot Grunberg
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...
2021GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis
Giovanni D'Angelo, Charlotte Julie Caroline Gehin, Laura Capolupo, Riccardo Rizzo
The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific cisternae along the cis-trans axis of the organelle. How such compartment ...
WILEY2021BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy
Matteo Dal Peraro, Mykola Dergai, Ying Hu
BET1 is required, together with its SNARE complex partners GOSR2, SEC22b, and Syntaxin-5 for fusion of endoplasmic reticulum-derived vesicles with the ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi. Here, we report three individuals, from two ...
WILEY2021Mammalian membrane trafficking as seen through the lens of bacterial toxins
Françoise Gisou van der Goot Grunberg, Francisco De Magalhães Sarmento R De Mesquita, Oksana Andrei Sergeeva
A fundamental question of eukaryotic cell biology is how membrane organelles are organised and interact with each other. Cell biologists address these questions by characterising the structural features of membrane compartments and the mechanisms that coor ...
WILEY2020Characterization of Protein-Membrane Interfaces through a Synergistic Computational-Experimental Approach
The characterization of biological interfaces is widely recognized as one of the main challenges for modern biology. In particular, biological membranes are nowadays known to be an active environment that allows membrane proteins to perform their work and ...
EPFL2020