Publication
Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae's environmental lifestyle
Related publications (44)
Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system
Melanie Blokesch, Anne-Florence Raphaëlle Bitbol, Alexandre Lemopoulos, Richard Marie Servajean, Simon Bernhard Otto
The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system’s dependency on contact, cellular interactions can lead to either competition or kin protection. Cell-to-ce ...
2024Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system
Melanie Blokesch, Anne-Florence Raphaëlle Bitbol, Alexandre Lemopoulos, Richard Marie Servajean, Simon Bernhard Otto
The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system's dependency on contact, cellular interactions can lead to either competition or kin protection. Cell-to-ce ...
2023Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae
Alexandre Louis André Persat, Sofya Mikhaleva
Biofilm formation is generally recognized as a bacterial defense mechanism against environmental threats, including antibiotics, bacteriophages, and leukocytes of the human immune system. Here, we show that for the human pathogen Vibrio cholerae, biofilm f ...
CELL PRESS2023Sporadic type VI secretion in seventh pandemic Vibrio cholerae
Melanie Blokesch, Sandrine Stutzmann, Nicolas René Chiaruttini, Alexis Joseph Proutière, Loriane Bader, Lisa Christina Metzger, Natalia Carolina Drebes Dorr, Sandrine Natacha Isaac
Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...
2023How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior
The bacterium Vibrio cholerae is the causative agent of the diarrheal disease cholera, which affects millions of people every year. Apart from being a human pathogen, V. cholerae is also a common member of aquatic habitats. Whilst the mechanism that allow ...
EPFL2022Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon
Natural competence for transformation is an important driver of horizontal DNA exchange between different organisms. This can result in accumulation of dangerous genetic features, such as antibiotic resistance genes, in a single organism. One example of an ...
EPFL2022Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae
Melanie Blokesch, Sandrine Stutzmann, Alexis Joseph Proutière, Loriane Bader, Natalia Carolina Drebes Dorr, Milena Jadwiga Jaskolska
Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...
2022A single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae
Melanie Blokesch, Sandrine Stutzmann, Alexis Joseph Proutière, Loriane Bader, Milena Jadwiga Jaskolska
Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...
2022Solving the mystery of the missing plasmids in seventh pandemic Vibrio cholerae strains
The pathogen responsible for the continuing seventh cholera pandemic typically lacks self-replicating plasmids. Genetics, cell biology and bioinformatics analyses have identified two DNA-defence systems that protect bacterial populations from plasmids and ...
2022The molecular treasure box of environmental Vibrio cholerae strains
Cholera pandemics have been affecting humankind for centuries and are still considered a major public health problem, especially in regions around the world with poor access to clean water and sanitation. Cholera pandemics are caused by a specific lineage ...
EPFL2021