Apparatus for non-invasively computing cardio-vasculature parameters using morphology of uncalibrated pressure wave signal

Systems and apparatus are provided for using a non-invasively monitored uncalibrated pressure signal from a patient to compute cardiac output and other cardio-vascular parameters, thereby providing safe, effective, reliable and low cost monitoring of patient health. Wearable devices are disclosed that include a sensor array for obtaining patient data that is used to provide an estimate of aortic systolic blood pressure, cardiac output, and end-systolic elastance that may be determined without the need for a cuff.