Publication

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Related publications (38)

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Long-term plasticity induces sparse and specific synaptic changes in a biophysically detailed cortical model

Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Marwan Muhammad Ahmed Abdellah, Pramod Shivaji Kumbhar, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander, Jorge Blanco Alonso, Giuseppe Chindemi, Ioannis Magkanaris

Synaptic plasticity underlies the brain’s ability to learn and adapt. This process is often studied in small groups of neurons in vitro or indirectly through its effects on behavior in vivo. Due to the limitations of available experimental techniques, inve ...

2023

Principles of Network Plasticity in Neocortical Microcircuits

András Ecker

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

EPFL2023

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

Mickael Maurice Zbili

Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity of synaptic transmission. However, the mechanisms linking the two forms of homeostatic regulation have not been identified so far. Using electrophysiological, im ...

NATL ACAD SCIENCES2021

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

FRONTIERS MEDIA SA2019

, , , , ,

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

Neurons process information through spatiotemporal integration of synaptic input. Synaptic transmission between any given pair of neurons is typically a dynamic process with presynaptic action potentials (APs) evoking depressing or facilitating postsynapti ...

Oxford Univ Press Inc2017

Monitoring dopamine and norepinephrine (or other structurally similar neurotransmitters) in the same brain region necessitates selective sensing. In this Viewpoint, we highlight electrochemical and optical strategies for advancing simultaneous real-time me ...

2017

Classical Hebbian learning puts the emphasis on joint pre- and postsynaptic activity, but neglects the potential role of neuromodulators. Since neuromodulators convey information about novelty or reward, the influence of neuromodulators on synaptic plastic ...

Frontiers Research Foundation2016

Synapses are key elements for communication within the complex network of neurons that make up our brain. Interestingly, synaptic connections can differ greatly in form and function, depending on the specific circuit into which they are embedded. In this P ...

EPFL2016

A CMOS Amperometric System for Multi-Neurotransmitter Detection

Giovanni De Micheli, Sandro Carrara

In vivo multi-target and selective concentration monitoring of neurotransmitters can help to unravel the brain chemical complex signaling interplay. This paper presents a dedicated integrated potentiostat transducer circuit and its selective electrode inte ...

Ieee-Inst Electrical Electronics Engineers Inc2016