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Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass
Related publications (33)
The interplay between white adipose tissue, adipokines, and structural gray matter changes
Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Liana Okudzhava
The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct f ...
Wiley2024White adipose tissue distribution and amount are associated with increased white matter connectivity
Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch, Liana Okudzhava
Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...
Hoboken2024Cross-anatomical single-cell definition and characterization of human adipose progenitor niche
Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...
EPFL2023A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function
White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated com ...
EPFL2023The role and transcriptional regulation of FAM46A in adipocyte differentiation
Obesity is currently a leading global health concern. Treatments include undergoing a weight-loss regimen. However, successful weight-loss is variable, where the heritability of obesity is considered part of the cause. This patient variability to weight-lo ...
EPFL2021The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling
The adipose tissue is increasingly recognized for the important role it plays in various diseases and pathological conditions, such as obesity, diabetes, cardiovascular diseases, osteoporosis, cancer, and aging. Despite its long-held reputation for being a ...
EPFL2019Gene regulatory dynamics underlying brown fat cell differentiation
Adipose tissue is increasingly recognized as a dynamic, endocrine organ responsible for regulating metabolic homeostasis via the collective action of its two principal subtypes: white adipose tissue (WAT) and brown adipose tissue (BAT). Recently, the disco ...
EPFL2017A systems perspective on brown adipogenesis and metabolic activation
Bart Deplancke, Magda Zachara, Rachana Narendra Pradhan
Brown adipocytes regulate energy expenditure via mitochondrial uncoupling. This makes these fat cells attractive therapeutic targets to tackle the burgeoning issue of obesity, which itself is coupled to insulin resistance, type 2 diabetes, cardiovascular a ...
Wiley-Blackwell2017Mfn2 is critical for brown adipose tissue thermogenic function
Carlos Canto Alvarez, Joanna Ratajczak, Miriam Valera Alberni
Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondri ...
Wiley2017SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
Carlos Canto Alvarez, Joanna Ratajczak, Pablo Jose Fernandez Marcos
Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...
Elsevier Science Bv2015