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Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala

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The dopaminergic VTA - basal amygdala projection contributes to signal aversive state in fear memory

Wei Tang

Dopamine released from midbrain neurons is an important neuromodulatory signal during associative learning in many forebrain circuits. One model of associative learning is auditory cued fear learning, during which an innocuous sensory percept like a tone ( ...

EPFL2018

The mysteries of remote memory

Johannes Gräff, Zimbul Albo

Long-lasting memories form the basis of our identity as individuals and lie central in shaping future behaviours that guide survival. Surprisingly, however, our current knowledge of how such memories are stored in the brain and retrieved, as well as the dy ...

2018

The brain is a complex biological system composed of a multitude of microscopic processes, which together give rise to computational abilities observed in everyday behavior. Neuronal modeling, consisting of models of single neurons and neuronal networks at ...

EPFL2017

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Experimental measurements of pairwise connection probability of pyramidal neurons together with the distribution of synaptic weights have been used to construct randomly connected model networks. However, several experimental studies suggest that both wiri ...

Frontiers Research Foundation2017

Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories

Johannes Gräff, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist ...

Hindawi Publishing Corp2016

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Pierre Magistretti, Sylvain Eric Lengacher, Virginia Gao

Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic recepto ...

National Academy of Sciences2016

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot

The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons active ...

Wiley-Blackwell2016

Involvement of CRFR1 in the basolateral amygdala in the immediate fear extinction deficit

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis

Several animal and clinical studies have highlighted the ineffectiveness of fear extinction sessions delivered shortly after trauma exposure. This phenomenon, termed the immediate extinction deficit, refers to situations in which extinction programs applie ...

2016

Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks

Wulfram Gerstner, Friedemann Zenke

Synaptic plasticity, the putative basis of learning and memory formation, manifests in various forms and across different timescales. Here we show that the interaction of Hebbian homosynaptic plasticity with rapid non-Hebbian heterosynaptic plasticity is, ...

Nature Publishing Group2015

Neurons utilize mitochondrial oxidative phosphorylation (OxPhos) to generate energy essential for survival, function, and behavioral output. Unlike most cells that burn both fat and sugar, neurons only burn sugar. Despite its importance, how neurons meet t ...

Cell Press2015