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The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Related publications (41)

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Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and pr ...

Frontiers Research Foundation2015

The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

Nouchine Hadjikhani, Loyse Hippolyte

Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for a ...

Nature Publishing Group2015

Ellipse-Preserving Hermite Interpolation and Subdivision

Michaël Unser

We introduce a family of piecewise-exponential functions that have the Hermite interpolation property. Our design is motivated by the search for an effective scheme for the joint interpolation of points and associated tangents on a curve with the ability t ...

Elsevier2015

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Vassily Hatzimanikatis, Julien Racle, Adam Stefaniuk

Noise in genetic networks has been the subject of extensive experimental and computational studies. However, very few of these studies have considered noise properties using mechanistic models that account for the discrete movement of ribosomes and RNA pol ...

Amer Inst Physics2015

The term ‘translational research’ appeared in Pubmed for the first time around 1993 (van der Laan & Boenink, 2012). Translational research aims to identify and challenge the “translational gaps’’ (T gaps) hindering the transformation of discoveries in the ...

2015

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Nonlinear microscopes have seen an increase in popularity in the life sciences due to their molecular and structural specificity, high resolution, large penetration depth, and volumetric imaging capability. Nonetheless, the inherently weak optical signals ...

American Chemical Society2014

Emotional contagion for pain is intact in autism spectrum disorders

Nouchine Hadjikhani, Loyse Hippolyte, Ophélie Rogier, Torsten Ruest

Perceiving others in pain generally leads to empathic concern, consisting of both emotional and cognitive processes. Empathy deficits have been considered as an element contributing to social difficulties in individuals with autism spectrum disorders (ASD) ...

Nature Publishing Group2014

Hyper-emotional neurophysiology in a rat model of autism

Mônica Regina Favre

Autism is a pervasive neurodevelopmental disorder of unknown etiology, characterized by a spectrum of symptoms of social impairment, abnormal communication, and unusual restricted, inflexible behaviors. Patients also frequently present various levels of se ...

EPFL2013

Computational analysis of the interplay between tRNA competitive behavior and decoding type on the modulation of translation elongation rate

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

There has been much discussion in the literature regarding the determinants of ribosomal decoding speed during the mRNA translation process. Computational results based on mechanistic models for ribosomal kinetics have predicted a major role for near-cogna ...

2013

Analysis of the dynamics and competition for resources in the system of protein translation using stochastic simulations

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Protein synthesis plays an important role in biological systems since its products, proteins and enzymes, constitute most of the molecular machinery required for cell regulation, growth and function in the tissue. Understanding the mechanisms of decoding a ...

2013