Publication
The interplay between white adipose tissue, adipokines, and structural gray matter changes
Related publications (51)
White adipose tissue distribution and amount are associated with increased white matter connectivity
Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch, Liana Okudzhava
Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...
Hoboken2024Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass
Johan Auwerx, Xiaoxu Li, Jun Yong Kim, Maroun Bou Sleiman, Yoo Hoon Kim
Adipose tissues serve as an energy reservoir and endocrine organ, yet the mechanisms that coordinate these functions remain elusive. Here, we show that the transcriptional coregulators, YAP and TAZ, uncouple fat mass from leptin levels and regulate adipocy ...
Nature Portfolio2024eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress
Johan Auwerx, Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, João Pedro de Matos Rodrigues, Ioannis Zalachoras, Wei Huang, Sriparna Ghosal, Laia Morato Fornaguera, Lei Cao
Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes in visceral fat deposition and in social behaviors. However, whether stress-induced changes in adipose tissue can affect fat-to-b ...
2022Mapping of Structure-Function Age-Related Connectivity Changes on Cognition Using Multimodal MRI
Dimitri Nestor Alice Van De Ville, Maria Giulia Preti
The relationship between age-related changes in brain structural connectivity (SC) and functional connectivity (FC) with cognition is not well understood. Furthermore, it is not clear whether cognition is represented via a similar spatial pattern of FC and ...
FRONTIERS MEDIA SA2022The perspectives of mapping and monitoring of the sense of self in neurosurgical patients
Olaf Blanke, Bruno Herbelin, Hyeongdong Park, Sophie Jacqueline Andrée Betka, Pavo Orepic, Sixto Luis Alcoba Banqueri, Giannina Rita Iannotti
Surgical treatment of tumors, epileptic foci or of vascular origin, requires a detailed individual pre-surgical workup and intra-operative surveillance of brain functions to minimize the risk of post-surgical neurological deficits and decline of quality of ...
SPRINGER WIEN2021Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and ...
BMJ PUBLISHING GROUP2021The role and transcriptional regulation of FAM46A in adipocyte differentiation
Obesity is currently a leading global health concern. Treatments include undergoing a weight-loss regimen. However, successful weight-loss is variable, where the heritability of obesity is considered part of the cause. This patient variability to weight-lo ...
EPFL2021Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
Perturbation of mitochondrial proteostasis provokes cell autonomous and cell non-autonomous responses that contribute to homeostatic adaptation. Here, we demonstrate distinct metabolic effects of hepatic metabokines as cell non-autonomous factors in mice w ...
CELL PRESS2021Dynamics of brain function in preterm-born young adolescents
Lorena Gonçalves de Alcântara e Freitas Krikler
Preterm birth is a major risk factor for neurodevelopment impairments often only appearing later in life. The brain is still at a high rate of development during adolescence, making this a promising window for intervention. It is thus crucial to understand ...
EPFL2020Exploring dynamic functional connectivity by incorporating prior knowledge of brain structure
The synchronized firing of distant neuronal populations gives rise to a wide array of functional brain networks that underlie human brain function. Given the enormous perception, learning, and cognition potential of the human brain, it is not surprising th ...
EPFL2020