Publication
Background: Fetal brain MRI is increasingly used to complement ultrasound imaging. Images are processed using complex super-resolution reconstruction pipelines, which may bias biometric and volumetric measurements. Objective: To assess the consistency of 2-dimensional (D) biometric and 3-D volumetric measurements across three hospitals using three widely used super-resolution reconstruction pipelines. Materials and methods: This retrospective multi-centric study used T2-weighted fetal brain MRI scans acquired at three hospitals between 2009 and 2023. MRIs from each subject were reconstructed with each super-resolution reconstruction method, and biometric measurements were performed by four experts. Automated 3-D volumetry was performed using a state-of-the-art segmentation method. A qualitative evaluation assessed the clinicians’ likelihood of using super-resolution reconstructed volumes in their practice. Results: Eighty-four healthy subjects were included. Biometric measurements revealed statistically significant changes that consistently remained below voxel width (0.8 mm; P