Publications related to Detection of Farnesyltransferase Interface Hot Spots through Computational Alanine Scanning Mutagenesis

Component reuse in structural design: emerging practices and tools for the circular economy

Corentin Jean Dominique Fivet, Jonas Warmuth, Pierluigi D'Acunto, Jan Friedrich Georg Brütting

Structural engineers play an increasing role in ensuring the transition towards a more sustainable construction sector: a) they are responsible for the design of the most resource- and energy-intensive part of buildings and infrastructure, and b) they regu ...

fib2021

The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

Stewart Cole, Florence Pojer

The cyclic AMP-dependent transcriptional regulator GlxR from Corynebacterium glutamicum is a member of the super-family of CRP/FNR (cyclic AMP receptor protein/fumarate and nitrate reduction regulator) transcriptional regulators that play central roles in ...

Public Library of Science2014

Inferring about individual drug and schizotypy effects on cognitive functioning in polydrug using mephedrone users before and after clubbing

Christine Mohr, Daniela Herzig

Objective Mephedrone has been recently made illegal in Europe, but little empirical evidence is available on its impact on human cognitive functions. We investigated acute and chronic effects of mephedrone consumption on drug-sensitive cognitive measures, ...

Wiley-Blackwell2013

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

Stewart Cole, Florence Pojer, Elizabeth Fullam

The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme. Here, we report on the structural and kinetic characterization of the transketola ...

Royal Soc2012

Comparison of velocimeter and coherent LIDAR measurements for building frequency assessment

Clotaire Michel

Over recent years there has been a growing interest in the building frequency analysis for earthquake and structural engineering fields using ambient vibrations. Simultaneously, velocity measurements with LASER remote sensing techniques have gained more in ...

Springer Verlag2010

Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Abhishek Garg

Personalized therapy requires accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecules cocktails, direct monitoring of ...

2009

Water-soluble prodrugs of cyclosporine A with tailored conversion rates

Arnaud Hamel

A novel type of water-soluble prodrugs of cyclosporine A (CsA) is described, featuring a modular system of an enzyme-cleavable group, a solubilizing moiety and a chemodegradable spacer attached to the hydroxyl function of (4R)-4-[(E)-2-butenyl]-4-,N-dimeth ...

2005