Automated computer-assisted quantitative analysis of intact murine lungs at the alveolar scale

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Inhalation of Microplastics—A Toxicological Complexity

Florian Frédéric Vincent Breider, Myriam Borgatta

Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat to human health. Inhalation toxicological studies are crucial for assessing the e ...

2024

Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening

Jiancheng Yang, Zhiye Wang, Jun Lu, Zhigang Li, Lin Qi, Ming Li, Bo Du, Yuxuan Sun, Ziyi Liu

Objectives Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM from inspiratory chest CT scans can eff ...

BMC2023

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the prefe ...

2023

Imaging atelectrauma in Ventilator-Induced Lung Injury using 4D X-ray microscopy

Goran Lovric, Anders Larsson

Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain poorly understood. Here we investigated the within-tidal dynamics of cyclic recru ...

NATURE RESEARCH2021

Deep learning architectures for estimating breathing signal and respiratory parameters from speech recordings

Mathew Magimai Doss, Zohreh Mostaani, Venkata Srikanth Nallanthighal

Respiration is an essential and primary mechanism for speech production. We first inhale and then produce speech while exhaling. When we run out of breath, we stop speaking and inhale. Though this process is involuntary, speech production involves a system ...

PERGAMON-ELSEVIER SCIENCE LTD2021

FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components

Lalit Kumar Dubey

Aspergillus fumigatus (A. fumigatus) is a ubiquitous fungus of clinical importance associated with development of various pulmonary diseases and allergic hypersensitivity reactions. It is protected against environmental stress by a cell wall that contains ...

FRONTIERS MEDIA SA2018

Tomographic in vivo microscopy for the study of lung physiology at the alveolar level

Goran Lovric, Marco Stampanoni

Lungs represent the essential part of the mammalian respiratory system, which is reflected in the fact that lung failure still is one of the leading causes of morbidity and mortality worldwide. Establishing the connection between macroscopic observations o ...

Nature Research2017

Effective segmentation of fresh post-mortem murine lung parenchyma in phase contrast X-ray tomographic microscopy images

Goran Lovric, Marco Stampanoni

The acinus represents the functional unit of the mammalian lung. It is defined as the small tree of gas-exchanging airways, which is fed by the most distal purely conducting airway. Different hypotheses exist on how the fine structure of the acinus changes ...

Iop Publishing Ltd2017

A 3-D Riesz-Covariance Texture Model for Prediction of Nodule Recurrence in Lung CT

Adrien Raphaël Depeursinge

This paper proposes a novel imaging biomarker of lung cancer relapse from 3-D texture analysis of CT images. Three-dimensional morphological nodular tissue properties are described in terms of 3-D Riesz-wavelets. The responses of the latter are aggregated ...

Institute of Electrical and Electronics Engineers2016

Homogenization of a multiscale viscoelastic model with nonlocal damping, application to the human lungs

Paul Isaac Denis Louis Marie Cazeaux

We are interested in the mathematical modeling of the deformation of the human lung tissue, called the lung parenchyma, during the respiration process. The parenchyma is a foam-like elastic material containing millions of air-filled alveoli connected by a ...

World Scientific Publ Co Pte Ltd2015