PEG-based hybrid block copolymers containing α-helical coiled coil peptide sequences: Control of self-assembly and preliminary biological evaluation
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The outer membrane protein OmpF from Escherichia coli is a member of a large family of b-barrel membrane proteins. Some, like OmpF, are pore-forming proteins while others are active transporters or enzymes. We have previously shown that the receptor-bindin ...
Herein we describe the structure and dynamics of self-assembled nano-objects generated from poly(ethylene glycol) based (PEG-ylated) coiled-coil hybrid block copolymers. Electron paramagnetic resonance (EPR) experiments on spin-labeled samples provided a s ...
This paper describes the supramolecular organization of a novel de novo designed metalloprotein, which consists of two N-terminal terpyridine modified coiled-coil protein folding motif sequences held together by an iron(II) ion. The self-assembly of the me ...
This paper discusses the solid state and melt nanoscale structure of a series of novel poly(ethylene glycol) (PEG) hybrid di- and triblock copolymers, which contain amphiphilic β-strand peptide sequences. The block copolymers have been prepared via solid-p ...
High-d. microarrays of attoliter vol. elements can be created within minutes in a parallel and effortless manner by using self-assembly of nanometer-size components based on biol. recognition. These ultrasmall vols. allow localization of single mols., scre ...
A detailed study of the supramolecular organization of two series of peptide-based diblock oligomers is reported. The diblock oligomers are comprised of an α-helical oligopeptide rod, which is either based on γ-benzyl-L-glutamate or ε-benzyloxycarbonyl-L-l ...
Nanostructures are known to exhibit novel optical, electrical, and magnetic and many other interesting physical properties and a lot of research has been invested on the synthesis and study of such structures in the recent years. The massive drive towards ...
Synthesis of nanostructures using polymer self-assembly methods have gained widespread attention due to the multitude of possibilities they offer and their simple and cost-effective approaches. Self-assembly of block copolymers has been recognized as a pro ...
This paper describes the synthesis and supramolecular organization of two novel hybrid diblock copolymers based on poly(ethylene glycol) (PEG) and peptide sequences inspired by the coiled coil protein folding motif. The self-organization of the diblock cop ...
This review discusses the potential of block copolymer type macromolecular building blocks for the preparation of self-assembled materials. Three different classes of block copolymer type architectures will be distinguished: i) coil-coil diblock copolymers ...