Self-assembled nanostructures from peptide-synthetic hybrid block copolymers: Complex, stimuli-responsive rod-coil architectures

Harm-Anton Klok
2005
Journal paper

The synthesis, solution and solid state self-assembly properties of a series of polyisoprene-b-poly(ε-benzyloxycarbonyl-L-lysine) PI-b-PZLys and polyisoprene-b-poly(L-lysine) PI-b-PLys block copolymers have been examined. The formation of stimuli-responsive micelles in water has been studied as a function of pH and ionic strength using static and dynamic light scattering, UV-circular dichroism and transmission electron microscopy. The observed change in the micelles dimensions has been directly attributed to the conformational transition in the secondary structure of polypeptide chains. In bulk, these rod-coil copolymers form self-assembled structures that have been characterized using DSC, DMA, WAXS and SAXS techniques. Hexagonal in lamellar (HL) and more interestingly hexagonal in hexagonal (HH) morphologies have been evidenced as a function of the chemical composition.

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Harm-Anton Klok
2005
Journal paper

Abstract

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https://infoscience.epfl.ch/record/52120?ln=en

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Nanoparticles are classified as having at least one of three dimensions be in the range of 1-100 nm. The small size of nanoparticles allows them to have unique characteristics which may not be possible on the macro-scale. Self-assembly is the spontaneous organization of smaller subunits to form larger, well-organized patterns. For nanoparticles, this spontaneous assembly is a consequence of interactions between the particles aimed at achieving a thermodynamic equilibrium and reducing the system’s free energy.

Self-assembly

Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure or pattern as a consequence of specific, local interactions among the components themselves, without external direction. When the constitutive components are molecules, the process is termed molecular self-assembly. Self-assembly can be classified as either static or dynamic. In static self-assembly, the ordered state forms as a system approaches equilibrium, reducing its free energy.

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