A platform for experimental precision medicine: The extended BXD mouse family

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The SNP-Based Profiling of Montecristo Feral Goat Populations Reveals a History of Isolation, Bottlenecks, and the Effects of Management

The Montecristo wild goat is an endangered feral population that has been on the homonymous island in the Tuscan Archipelago since ancient times. The origins of Montecristo goats are still debated, with authors dating their introduction either back to Neol ...

MDPI2022

The genetic architecture of complex human traits at the dawn of genomic medicine

Olivier Noël Marie Naret

The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

EPFL2021

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Jacques Fellay, John Wilson, Yang Luo, Xinyi Li

A high-resolution reference panel based on whole-genome sequencing data enables accurate imputation of HLA alleles across diverse populations and fine-mapping of HLA association signals for HIV-1 host response. ...

NATURE PORTFOLIO2021

Stabilization of cultural innovations depends on population density: Testing an epidemiological model of cultural evolution against a global dataset of rock art sites and climate-based estimates of ancient population densities

John Richard Walker, Taylor Howard Newton, Francesco Casalegno

Demographic models of human cultural evolution have high explanatory potential but weak empirical support. Here we use a global dataset of rock art sites and climate and genetics-based estimates of ancient population densities to test a new model based on ...

2021

Validating model-based data interpretation methods for quantification of reserve capacity

Ian Smith, Sai Ganesh Sarvotham Pai

Optimal performance of civil infrastructure is an important aspect of liveable cities. A judicious combination of physics-based models with monitoring data in a validated methodology that accounts for uncertainties is explored in this paper. This methodolo ...

2021

The Imitation Game: Algorithm Selection by Exploiting Black-Box Recommenders

Rachid Guerraoui, Georgios Damaskinos

Cross-validation is commonly used to select the recommendation algorithms that will generalize best on yet unknown data. Yet, in many situations the available dataset used for cross-validation is scarce and the selected algorithm might not be the best suit ...

Springer2021

HIV-1 and human genetic variation

Jacques Fellay

Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV i ...

NATURE RESEARCH2021

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Henry Markram, Emmanuelle Logette, Samuel Claude Kerrien, Enrico Scantamburlo, Daniel Keller, Jay Coggan, Cyrille Pierre Henri Favreau, Francesco Casalegno, Mohameth François Sy, Anna-Kristin Kaufmann

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that reached pandemic proportions among the human population within months. The reasons for the spectrum of differences in the severity of the disease across the population, an ...

FRONTIERS MEDIA SA2021

L-mode plasmas analyses and current ramp-up predictions for a JT-60SA hybrid scenario

Timothy Goodman, Javier García Hernández, Matteo Vallar

In this work, L-mode analyses are performed in order to assess a modeling framework for the prediction of electron cyclotron resonant heating (ECRH) -assisted current ramp-up phases for JT-60SA tokamak hybrid scenario #4-2. We compare two turbulence transp ...

IOP PUBLISHING LTD2021

Ten seconds of my nights: Exploring methods to measure brightness, loudness and attendance and their associations with alcohol use from video clips

Daniel Gatica-Perez, Skanda Muralidhar, Lakmal Buddika Meegahapola

Introduction Most evidence on associations between alcohol use behaviors and the characteristics of its social and physical context is based on self-reports from study participants and, thus, only account for their subjective impressions of the situation. ...

2021

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