Publications related to Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

Aip Publishing2024

Novel theory and potential applications of central diastolic pressure decay time constant

Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia, Patrick Segers

Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...

2024

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

Apparatus for non-invasively computing cardio-vasculature parameters using morphology of uncalibrated pressure wave signal

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

Systems and apparatus are provided for using a non-invasively monitored uncalibrated pressure signal from a patient to compute cardiac output and other cardio-vascular parameters, thereby providing safe, effective, reliable and low cost monitoring of patie ...

2024

A machine learning architecture for including wave breaking in envelope-type wave models

Debbie Eeltink, Yuxuan Liu

Wave breaking is a complex physical process about which open questions remain. For some applications, it is critical to include breaking effects in phase-resolved envelope-based wave models such as the non-linear Schr & ouml;dinger. A promising approach is ...

Pergamon-Elsevier Science Ltd2024

Multimodal transcriptomic atlases of mouse spinal cord injury

Matthieu Pierre Gautier

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

EPFL2024

When Subtyping Constraints Liberate A Novel Type Inference Approach for First-Class Polymorphism

Lionel Emile Vincent Parreaux, Aleksander Slawomir Boruch-Gruszecki

Type inference in the presence of first-class or "impredicative" second-order polymorphism a la System F has been an active research area for several decades, with original works dating back to the end of the 80s. Yet, until now many basic problems remain ...

Assoc Computing Machinery2024

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

Alfio Quarteroni

Stroke, a major global health concern often rooted in cardiac dynamics, demands precise risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2 -VASc \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepa ...

Nature Portfolio2024

The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach

Nikolaos Stergiopoulos

The transaortic valvular pressure gradient (TPG) plays a central role in decision-making for patients suffering from severe aortic stenosis. However, the flow-dependence nature of the TPG makes the diagnosis of aortic stenosis challenging since the markers ...

MDPI2023

Compliance-matching vascular grafts with personalization potential

Georgios Rovas

Aortic diseases are characterized by dire prognosis and inadequate diagnosis, owing to their insidious yet lethal nature. Aortopathies, namely aortic aneurysms and dissections, along with certain congenital diseases, might necessitate surgical replacement ...

EPFL2023