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Hormone receptor signaling in estrogen receptor positive breast cancer

Related publications (29)

Unveiling breast cancer metastasis through an advanced X-ray imaging approach

Breast cancer is a significant global health burden, causing a substantial number of deaths. Systemic metastatic tumour cell dissemination is a major cause of poor outcomes. Understanding the mechanisms underlying metastasis is crucial for effective interv ...

Nature Portfolio2024

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Moritz Hofer

Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...

EPFL2024

Next-Generation Modeling of Cancer Using Organoids

Wouter Richard Karthaus, Jillian Rose Love

In the last decade, organoid technology has become a cornerstone in cancer research. Organoids are long-term primary cell cultures, usually of epithelial origin, grown in a three-dimensional (3D) protein matrix and a fully defined medium. Organoids can be ...

Cold Spring Harbor Lab Press, Publications Dept2024

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Alex Russell Lederer

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

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Engineering hydrogel microenvironments for epithelial organoid culture

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Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...

EPFL2024

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Fides Zenk

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity has been di ...

Nature Portfolio2024

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Sarah Emmert

Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...

EPFL2024

Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity

Nadine Fournier, Manon Bulliard, Annamaria Kauzlaric, Yu-Ting Huang, Rachel Marcone

Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underl ...

Amer Soc Clinical Investigation Inc2024

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Luc Reymond, Fabien Kuttler, Milena Maria Schuhmacher, Manon Sandra Bardyn, Daria Korotkova, Triana Amen

Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

Nature Research2024

Hormone receptor signaling in estrogen receptor positive breast cancer

Unveiling breast cancer metastasis through an advanced X-ray imaging approach

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Next-Generation Modeling of Cancer Using Organoids

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Engineering hydrogel microenvironments for epithelial organoid culture

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

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Unveiling breast cancer metastasis through an advanced X-ray imaging approach

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Next-Generation Modeling of Cancer Using Organoids

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Engineering hydrogel microenvironments for epithelial organoid culture

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells