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Protein de novo design

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Extending the concept of template-assembled synthetic proteins

A review with 56 refs. The creation of native-like macromols. in copying nature's way represents a fascinating challenge in protein chem. today. In the absence of detailed knowledge of the complex folding pathway, the ultimate goal in protein de novo desig ...

1999

Solid-phase strategies for the assembly of template-based protein mimetics

The template concept for overcoming the protein folding problem in protein de novo design has recently been extended for mimicking essential structural and functional features of proteins. Due to progress in synthetic methodologies, template-assembled cons ...

1999

Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells

Françoise Gisou van der Goot Grunberg

Tumor necrosis factor TNF can trigger increases in membrane conductance of mammalian cells in a receptor-independent manner via its lectin-like domain. A lectin-deficient TNF mutant, lacking this activity, was able to bind to artificial liposomes in a pH-d ...

1999

Peptide engineering: a trimeric \"locked-in\" zinc finger motif

A symposium report. The concept of template assembled synthetic proteins (TASP) has been evaluated for the locked-in fold derived from the DNA-binding bba zinc finger motif based on the consensus sequence Xaa3-Cys-Xaa2-4-Cys-Xaa12-His-Xaa3-4-His-Xaa4 to mi ...

1999

Synthesis and pharmacological properties of an a-cyclodextrin assembled neuropeptide Y fragment

A symposium report. We report on the synthesis of TASP (template assembled synthetic proteins) mols. able to bind to neurotensin Y and angiotensin II receptors, in which a-cyclodextrin is used as template. [on SciFinder (R)] ...

1999

Protein design: on the threshold of functional properties

A review with several refs. The ultimate goal in protein de novo design is the creation of novel macromols. with tailor-made receptor, sensory, and catalytic functions. Despite considerable progress in understanding basic rules of secondary structure forma ...

1998

Template assembled binding loops as functional mimetics of receptors

Christian Lehmann

A symposium report on synthetic strategies which provide a synthetic entry to a new generation of template assembled synthetic proteins (TASP). [on SciFinder (R)] ...

1998

Non-native architectures in protein design and mimicry

A review is given with 62 refs. on the art of template-based protein de novo design, with special emphasis on progress in peptide synthesis and template design and show that some fundamental questions in protein assembly, structure and function can be appr ...

1997

Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example o ...

1997

Template assisted protein de novo design

A review with 38 refs. The ultimate goal in protein de novo design is the construction of artificial proteins exhibiting tailor-made structural and functional properties. To create native-like macromols. in copying nature's way had proven to be difficult b ...

1996