Template assembled binding loops as functional mimetics of receptors
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A symposium report. The concept of template assembled synthetic proteins (TASP) has been evaluated for the locked-in fold derived from the DNA-binding bba zinc finger motif based on the consensus sequence Xaa3-Cys-Xaa2-4-Cys-Xaa12-His-Xaa3-4-His-Xaa4 to mi ...
A symposium report. We report on the synthesis of TASP (template assembled synthetic proteins) mols. able to bind to neurotensin Y and angiotensin II receptors, in which a-cyclodextrin is used as template. [on SciFinder (R)] ...
A review with 38 refs. The ultimate goal in protein de novo design is the construction of artificial proteins exhibiting tailor-made structural and functional properties. To create native-like macromols. in copying nature's way had proven to be difficult b ...
A review with twenty-nine refs. on the authors' current research. Protein design and mimicry combines elements of synthetic org. chem. with structural and functional aspects of biol. relevance in a unique way. Due to progress in this interdisciplinary rese ...
A chimeric TASP (Template Assembled Synthetic Proteins) mol., consisting of a 4-helix bundle motif and an antibody recognition site, has been covalently attached to a gold surface. The reversible antibody binding to the self-assembled monolayer as monitore ...
The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example o ...
A bifacial topological template exhibiting metal-binding sites and thioalkane chains has been incorporated into self-assembled monolayers and immobilised on gold surfaces: These systems allow for the detection of external ligands by SPR spectroscopy repres ...
A review with 43 refs. on strategies for the synthesis of protein mimetics and artificial proteins. The ultimate goal in protein de novo design is the construction of artificial proteins inhibiting tailor-made structural and functional properties. To creat ...
A review, with 33 refs. The authors review here the template-assembled synthetic proteins concept and some of its extensions in peptide mimicry and supramol. chem. [on SciFinder (R)] ...
