Fusion proteinFusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins. Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins. Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics.
Drug designDrug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it.
Modern philosophyModern philosophy is philosophy developed in the modern era and associated with modernity. It is not a specific doctrine or school (and thus should not be confused with Modernism), although there are certain assumptions common to much of it, which helps to distinguish it from earlier philosophy. The 17th and early 20th centuries roughly mark the beginning and the end of modern philosophy. How much of the Renaissance should be included is a matter for dispute; likewise modernity may or may not have ended in the twentieth century and been replaced by postmodernity.
Modern eraThe modern era is the period of human history that succeeds the Middle Ages (which ended around 1500 AD) up to the present. This terminology is a historical periodization that is applied primarily to European and Western history. The modern era can be further divided as follows: The early modern period lasted from c. AD 1500 to 1800 and resulted in wide-ranging intellectual, political and economic change.
Early modern philosophyEarly modern philosophy (also classical modern philosophy) is a period in the history of philosophy that overlaps with the beginning of the period known as modern philosophy. The early modern era of philosophy was a progressive movement of Western thought, exploring through theories and discourse such topics as mind and matter, the supernatural, and civil life. It succeeded in the medieval era of philosophy. Early modern philosophy is usually thought to have occurred between the 16th and 18th centuries, though some philosophers and historians may put this period slightly earlier.
ProteoglycanProteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN). The Ser residue is generally in the sequence -Ser-Gly-X-Gly- (where X can be any amino acid residue but proline), although not every protein with this sequence has an attached glycosaminoglycan.
