Determination of homonuclear scalar coupling constants by combining selective two-dimensional NMR spectroscopy with convolution and deconvolution: applications to paclitaxel (taxol)
Graph Chatbot
Chat with Graph Search
Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.
DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.
The C-13-{H-1} NMR spectra of two monofluorinated nematic liquid crystals, I35 and I52, have been obtained and analysed to yield sets of dipolar couplings, D-iF, from each carbon in the molecule to the fluorine nucleus. The couplings involving carbons in t ...
The concentration of reduced glutathione (GSH), an antioxidant, may be altered in various brain diseases. MEGA-PRESS was used to edit for the (1)H NMR signal from GSH in the occipital lobe of 12 normal humans. In all studies, GSH was clearly detected with ...
Metabolite signals with short T1 or T2 are difficult to localize with full sensitivity. This limitation was overcome with the development and implementation of a single-shot, complete three-dimensional 'non-echo' localization method with reduced sensitivit ...
We present the design, fabrication and test of high-Q factor radiofrequency planar microcoils for nuclear magnetic resonance (NMR) spectroscopy in small volume samples. The coils are fabricated on glass wafers using high-aspect ratio SU-8 photoepoxy and co ...
Objective: Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinic ...
The variable-speed magic-angle sample spinning (VSMAS) technique was extended to two-dimensional spectroscopy in solids yielding two-dimensional spectra free of spinning sidebands. [on SciFinder (R)] ...
A wide variety of amplitude- or phase-modulated pulses, which are designed for selective excitation, inversion or refocusing, are severely perturbed by radiation damping effects in the presence of a large macroscopic magnetization. A general method is pres ...
We report site-resolved observation of hydrogen exchange in the micro-crystalline protein Crh. Our approach is based on the use of proton T-2(')-selective H-1-C-13-C-13 correlation spectra for site-specific assignments of carbons nearby labile protein prot ...
We show how high-resolution NMR spectra can be obtained for solids for which the spectra are normally broadened due to structural disorder. The method relies on correlations in the chemical shifts between pairs of coupled spins. It is found experimentally ...
A new solid-state NMR experiment, J-WISE, is presented for studying local mobility in solids with atomic resolution. The experiment correlates the wide-line proton spectrum with the isotropic chemical shift of carbon-13 via the J coupling between both nucl ...