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Chemistry of Pyranosyl-RNA, Part 8. Opposite orientation of backbone inclination in pyranosyl-RNA and homo-DNA correlates with opposite directionality of duplex properties

Related publications (33)

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Signal search analysis server

Giovanna Ambrosini, Philipp Bucher

Signal search analysis is a general method to discover and characterize sequence motifs that are positionally correlated with a functional site (e.g. a transcription or translation start site). The method has played an instrumental role in the analysis of ...

2003

Nucleotide detection by fluorescence resonance energy transfer and methods thereof

Gerardo Turcatti

The present invention provides novel methods for detecting the incorporation of a nucleotide after a single base extension reaction. The methods make use of the Fluorescence Resonance Energy Transfer (FRET) effect generated by two fluorophores linked to th ...

2003

Numerous potentially functional but non-genic conserved sequences on human chromosome 21

Philipp Bucher

The use of comparative genomics to infer genome function relies on the understanding of how different components of the genome change over evolutionary time. The aim of such comparative analysis is to identify conserved, functionally transcribed sequences ...

2002

Long-range heterogeneity at the 3' ends of human mRNAs

Philipp Bucher

The publication of a draft of the human genome and of large collections of transcribed sequences has made it possible to study the complex relationship between the transcriptome and the genome. In the work presented here, we have focused on mapping mRNA 3' ...

2002

trEST, trGEN and Hits: access to databases of predicted protein sequences

Philipp Bucher

High throughput genome (HTG) and expressed sequence tag (EST) sequences are currently the most abundant nucleotide sequence classes in the public database. The large volume, high degree of fragmentation and lack of gene structure annotations prevent effici ...

2001

Methods of nucleic acid amplification and sequencing

Gerardo Turcatti

Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified or sequenced, wherein said nucleic acid(s) contains at the 5 ...

2000

Improving the sensitivity of the sequence profile method

Philipp Bucher, Ioannis Xenarios

The sequence profile method (Gribskov M, McLachlan AD, Eisenberg D, 1987, Proc Natl Acad Sci USA 84:4355-4358) is a powerful tool to detect distant relationships between amino acid sequences. A profile is a table of position-specific scores and gap penalti ...

1994

Switch Peptides: pH‐Induced α‐Helix to β‐Sheet Transitions of Bis‐amphiphilic Oligopeptides

The interconversion of two secondary structure types (alpha-helix reversible beta-sheet) induced by external conditions such as pH, temperature, concentration, and solvent could be proved in a new class of amphiphilic peptides (switch peptides) in aqueous ...

1991

Defective endogenous retrovirus-like sequences and particles of Chinese hamster ovary cells

Florian Maria Wurm

The presence of budding C-type and intracytoplasmic A-type particles in Chinese hamster ovary (CHO) cells is well documented. However, extensive screening has failed to detect any evidence of infectivity. To investigate the origin and expression of these p ...

1991

Molecular genetic analysis of FNR-dependent promoters

Stewart Cole

In enteric bacteria, the expression of many genes encoding various anaerobic electron transfer functions is controlled by FNR, the product of the autoregulated fnr gene. FNR is structurally and functionally homologous to CAP, the catabolite gene activator ...

1989