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A review. The efficient anal. of the function of ion channels is an important task in many different fields ranging from (bio)analytics and drug-screening to nanoelectronics. Here, the modulation of the channel activity of a synthetic ligand gated ion channel by a specific antibody is measured in tethered lipid bilayers by impedance spectroscopy. Tethered single lipid bilayers with exceptionally high elec. resistances suitable for the detection of a few channels are presented. [on SciFinder (R)]
Gerardo Turcatti, Marc Chambon, Julien Bortoli Chapalay, Elena Goun, Jonathan Patrice Vesin, Arkadiy Bazhin, James William Collins
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Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Elena Katsyuba, Hüseyin Baris Atakan, Rongrong Xiang