Publication

A possible alternative mechanism for the oxidation of formaldehyde to formate

Ian William Marison
1982
Journal paper
Abstract

A survey of the occurrence of a no. of enzymes possibly involved in the C1 dissimilatory pathway in organisms using the serine pathway of C assimilation indicated that neither the methanol dehydrogenase nor the NH4-independent dye-linked formaldehyde dehydrogenase had a specific role in the oxidn. of formaldehyde. Conversely, the activities of enzymes involved in the methenyl-THF pathway were induced during growth on MeOH or MeNH2, suggesting a potential dissimilatory role for this pathway. [on SciFinder (R)]

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Enzyme
Enzymes (ˈɛnzaɪmz) are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps.
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Methanol toxicity (also methanol poisoning) is poisoning from methanol, characteristically via ingestion. Symptoms may include a decreased level of consciousness, poor or no coordination, vomiting, abdominal pain, and a specific smell on the breath. Decreased vision may start as early as twelve hours after exposure. Long-term outcomes may include blindness and kidney failure. Blindness may occur after drinking as little as 10 mL; death may occur after drinking quantities over 15 mL (median 100 mL, varies depending on body weight).
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