Physiologically based pharmacokinetic modellingPhysiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals. PBPK models strive to be mechanistic by mathematically transcribing anatomical, physiological, physical, and chemical descriptions of the phenomena involved in the complex ADME processes.
EquestrianismEquestrianism (from Latin equester, equestr-, equus, 'horseman', 'horse'), commonly known as horse riding (Commonwealth English) or horseback riding (American English), includes the disciplines of riding, driving, and vaulting. This broad description includes the use of horses for practical working purposes, transportation, recreational activities, artistic or cultural exercises, and competitive sport. Horses are trained and ridden for practical working purposes, such as in police work or for controlling herd animals on a ranch.
GeldingA gelding is a castrated male horse or other equine, such as a pony, donkey or a mule. The term is also used with certain other animals and livestock, such as domesticated camels. By comparison, the equivalent term for a castrated male bull would be ox (or oxen), or a wether for rams and billy goats. Castration (in addition to the elimination of hormonally-driven behavior associated with a stallion) allows a male animal to be more calm, better-behaved, less sexually-aggressive, and more responsive to training efforts.
Andreas VesaliusAndries van Wezel (31 December 1514 – 15 October 1564), latinised as Andreas Vesalius (vɪˈseɪliəs), was an anatomist and physician who wrote De Humani Corporis Fabrica Libri Septem (On the fabric of the human body in seven books), what is considered to be one of the most influential books on human anatomy and a major advance over the long-dominant work of Galen. Vesalius is often referred to as the founder of modern human anatomy. He was born in Brussels, which was then part of the Habsburg Netherlands.
Fox huntingFox hunting is a traditional activity involving the tracking, chase and, if caught, the killing of a fox, normally a red fox, by trained foxhounds or other scent hounds. A group of unarmed followers, led by a "master of foxhounds" (or "master of hounds"), follow the hounds on foot or on horseback. Fox hunting with hounds, as a formalised activity, originated in England in the sixteenth century, in a form very similar to that practised until February 2005, when a law banning the activity in England and Wales came into force.
Cmax (pharmacology)DISPLAYTITLE:Cmax (pharmacology) Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. It is a standard measurement in pharmacokinetics. Cmax is the opposite of Cmin, which is the minimum (or trough) concentration that a drug achieves after dosing. The related pharmacokinetic parameter tmax is the time at which the Cmax is observed.
Driving (horse)Driving, when applied to horses, ponies, mules, or donkeys, is a broad term for hitching equines to a wagon, carriage, cart, sleigh, or other horse-drawn vehicle by means of a harness and working them in this way. It encompasses a wide range of activities from pleasure driving, to harness racing, to farm work, horse shows, and even international combined driving. For horse training purposes, "driving" may also include the practice of long-lining (long reining), wherein a horse is driven without a cart by a handler walking behind or behind and to the side of the animal.
VenipunctureIn medicine, venipuncture or venepuncture is the process of obtaining intravenous access for the purpose of venous blood sampling (also called phlebotomy) or intravenous therapy. In healthcare, this procedure is performed by medical laboratory scientists, medical practitioners, some EMTs, paramedics, phlebotomists, dialysis technicians, and other nursing staff. In veterinary medicine, the procedure is performed by veterinarians and veterinary technicians.
Sampling (medicine)In medicine, sampling is gathering of matter from the body to aid in the process of a medical diagnosis and/or evaluation of an indication for treatment, further medical tests or other procedures. In this sense, the sample is the gathered matter, and the sampling tool or sampler is the person or material to collect the sample. Sampling is a prerequisite for many medical tests, but generally not for medical history, physical examination and radiologic tests.
Parenteral nutritionParenteral nutrition (PN) is the feeding of nutritional products to a person intravenously, bypassing the usual process of eating and digestion. The products are made by pharmaceutical compounding companies. The person receives a nutritional mix according to a formula including glucose, salts, amino acids, lipids and vitamins and dietary minerals. It is called total parenteral nutrition (TPN) or total nutrient admixture (TNA) when no significant nutrition is obtained by other routes, and partial parenteral nutrition (PPN) when nutrition is also partially enteric.
