Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering
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Carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue ...
Effective encapsulation of small, volatile, weakly water-soluble molecules such as flavors and fragrances is necessary to protect them from degradation, to increase their lifetime, and to improve their water dispersion and fixation depending on the substra ...
Two novel tetra- and hexahydroxy functionalized perylene chromophores have been used as initiators for the Sn(oct)2 catalyzed ring-opening polymerization of different lactones. The arms of the resulting star polymers were comprised of either crystallizable ...
Various surfaces can successfully be coated with reactive polymer coatings and then patterned with DNA features using supramocular nanostamping (SuNS). Surfaces as different as silicon, quartz, polystyrene, PMMA and PDMS have been patterned using the same ...
We present polymeric hydrogel biomaterials that are biomimetic both in their synthesis and degradation. The design of oligopeptide building blocks with dual enzymatic responsiveness allows us to create polymer networks that are formed and functionalized vi ...
A family of graft copolymers that can sterically inhibit interactions between biological surfaces was developed. These copolymers contained phenylboronic acid (PBA) groups as saccharide-binding moieties on a poly-(L-lysine) backbone and poly(ethylene glyco ...
This report demonstrates the feasibility of surface-initiated atom transfer radical polymerization to prepare thin polymer layers ("brushes") that can be functionalized with short peptide ligands and which may be of use as coatings to promote endothelializ ...
The morphology in the solid state of a series of triblock copolymers comprising a poly(ethylene glycol) (PEG) midblock and symmetric poly(γ-benzyl-L-glutamate) (PBLG) end blocks has been studied using X-ray scattering and microscopy techniques. Transmissio ...
A new class of water-soluble, amphiphilic star block copolymers with a large number of arms was prepared by sequential atom transfer radical polymerization (ATRP) of n-butyl methacrylate (BMA) and poly-(ethylene glycol) methyl ether methacrylate (PEGMA). A ...
Osteoblasts exhibit a more differentiated morphol. on surfaces with rough microtopogs. Surface effects are often mediated through integrins that bind the RGD motif in cell attachment proteins. Here, we tested the hypothesis that modulating access to RGD bi ...