Title amino acids I (R, R1, R2 = H, OMe) were prepd. from 2-arylethylamines II by a reaction sequence consisting of N-pivaloylation, lithiation at the benzylic position with tert-BuLi, carboxylation, and deprotection by refluxing in 20% hydrochloric acid. [on SciFinder (R)]
Philipp Georg Werner Seeberger
Alkynes are found in a multitude of natural or synthetic bioactive compounds. In addition to the capacity of these chemical motifs to impact the physicochemical properties of a molecule of interest, the well-established reactivity of alkynes makes them ...