Publications related to New methods for the investigation of RNA refolding by NMR spectroscopy

Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR

We introduce a new approach to improve structural and dynamical determination of large metalloproteins using solid-state nuclear magnetic resonance (NMR) with H-1 detection under ultrafast magic angle spinning (MAS). The approach is based on the rapid and ...

NATL ACAD SCIENCES2012

Rapid Measurement of Pseudocontact Shifts in Metalloproteins by Proton-Detected Solid-State NMR Spectroscopy

David Lyndon Emsley

Pseudocontact shifts (PCSs) arise in para-magnetic systems in which the susceptibility tensor is anisotropic. PCSs depend upon the distance from the paramagnetic center and the position relative to the susceptibility tensor, and they can be used as structu ...

AMER CHEMICAL SOC2012

A computational framework for the design of optimal protein synthesis

Vassily Hatzimanikatis, Julien Racle, Jan Overney

Despite the establishment of design principles to optimize codon choice for heterologous expression vector design, the relationship between codon sequence and final protein yield remains poorly understood. In this work, we present a computational framework ...

Wiley-Blackwell2012

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

Jérôme Waser, Fides Benfatti, Florian Patrick Marie Daniel De la Barre De Nanteuil

The first method for the [3 + 2] annulation of donor acceptor aminocyclopropanes with aldehydes is reported. The reaction is catalyzed by iron trichlorlde on alumina in yields up to 99% and with excellent cis selectivities (up to >20:1) and represents a st ...

American Chemical Society2012

Buckling-induced encapsulation of structured elastic shells under pressure

Pedro Miguel Nunes Pereira de Almeida Reis

We introduce a class of continuum shell structures, the Buckliball, which undergoes a structural transformation induced by buckling under pressure loading. The geometry of the Buckliball comprises a spherical shell patterned with a regular array of circula ...

2012

Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Jacques Fellay, Amalio Telenti, Istvan Bartha

Background: The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the sites of select ...

2011

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

Ursula Röthlisberger, Geoffrey Wood

The distinct conformational dependence of chemical shifts caused by R-helices and β-sheets renders NMR chemical shift analysis a powerful tool for the structural determination of proteins. However, the time scale of NMR experiments can make a secondary str ...

2011

A master-equation approach to the description of proton-driven spin diffusion from crystal geometry using simulated zero-quantum lineshapes

David Lyndon Emsley

Measurements of proton-driven carbon-13 spin diffusion (PDSD) by NMR spectroscopy are a central component of structural analyses of biomolecules in the solid-state. However, the quantitative link between experimental PDSD data and structural information is ...

ROYAL SOC CHEMISTRY2011

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New methods for the investigation of RNA refolding by NMR spectroscopy

Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR

Rapid Measurement of Pseudocontact Shifts in Metalloproteins by Proton-Detected Solid-State NMR Spectroscopy

A computational framework for the design of optimal protein synthesis

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

Buckling-induced encapsulation of structured elastic shells under pressure

Approximation Algorithms for the Interval Constrained Coloring Problem

Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

A master-equation approach to the description of proton-driven spin diffusion from crystal geometry using simulated zero-quantum lineshapes

Fast Resonance Assignment and Fold Determination of Human Superoxide Dismutase by High-Resolution Proton-Detected Solid-State MAS NMR Spectroscopy

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Approximation Algorithms for the Interval Constrained Coloring Problem

Buckling-induced encapsulation of structured elastic shells under pressure

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

Rapid Measurement of Pseudocontact Shifts in Metalloproteins by Proton-Detected Solid-State NMR Spectroscopy

Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR

Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

A computational framework for the design of optimal protein synthesis

Fast Resonance Assignment and Fold Determination of Human Superoxide Dismutase by High-Resolution Proton-Detected Solid-State MAS NMR Spectroscopy

A master-equation approach to the description of proton-driven spin diffusion from crystal geometry using simulated zero-quantum lineshapes