Publications related to Circuits and Systems for High-Throughput Biology

Low- to high-throughput analysis of telomerase modulators with Telospot

Joachim Lingner, Gerardo Turcatti, Marc Chambon, Damiano Banfi

We designed a method termed Telospot to discover and characterize telomerase modulators as anticancer drugs or chemical biology tools. Telospot is based on a highly efficient human telomerase expression system and the detection of telomerase DNA reaction p ...

2007

Controlled and localized genetic manipulation in the brain

Carl Petersen, Rachel Aronoff

Brain structure and function are determined in part through experience and in part through our inherited genes. A powerful approach for unravelling the balance between activity-dependent neuronal plasticity and genetic programs is to directly manipulate th ...

2006

Mining gene sets for measuring similarities

Giovanni De Micheli, Luca Benini

In recent years, the development of high throughput devices for the massive parallel analyses of genomic data has lead to the generation of large amount of new biological evidences and has triggered the proliferation of data mining algorithms for the extra ...

2006

Hardware/Software Coevolution of Genome Programs and Cellular Processors

Guillaume Zufferey, Pierre-André Mudry

The application of evolutionary techniques to the design of custom processing elements bears a strong relation to the natural process that led to the co-evolution of cells and genomes in biological organisms. As such, it is an interesting avenue for an eff ...

2006

Microfluidic Applications in Biology From Technologies to Systems Biology

Niels Erik Lion, Joël Stéphane Rossier

High-impact research articles on microfluidics and its application in biology and biotechnology. The articles have been selected from our popular Electrophoresis journal special issue. ...

Wiley-VCH2006

Similarities and differences of polyadenylation signals in human and fly

Felix Naef, Philipp Bucher

ABSTRACT: BACKGROUND: Cleavage of messenger RNA (mRNA) precursors is an essential step in mRNA maturation. The signal recognized by the cleavage enzyme complex has been characterized as an A rich region upstream of the cleavage site containing a motif with ...

2006

Adaptive Distributed Algorithms for Power-Efficient Data Gathering in Sensor Networks

Razvan Cristescu, Jugoslava Acimovic

In this work, we consider the problem of designing adaptive distributed processing algorithms in large sensor networks that are efficient in terms of minimizing the total power spent for gathering the spatially correlated data from the sensor nodes to a si ...

2005

A first version of the Caenorhabditis elegans Promoterome

Bart Deplancke

An important aspect of the development of systems biology approaches in metazoans is the characterization of expression patterns of nearly all genes predicted from genome sequences. Such "localizome" maps should provide information on where (in what cells ...

2004

Tree-Based Pursuit

Pascal Frossard, Pierre Vandergheynst, Philippe Jost

Building good sparse approximations of functions is one of the major themes in approximation theory. When applied to signals, images or any kind of data, it allows to deal with basic building blocks that essentially synthesize all the information at hand. ...

2004

Scaling Laws for Correlated Data Gathering

Martin Vetterli, Razvan Cristescu

Consider a set of correlated sources located at the nodes of a network, and a sink to which the data from all the sources has to arrive. We address the minimization of a separable joint communication cost function given by the product [rate]

\times

[edge ...

2004

Circuits and Systems for High-Throughput Biology

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Low- to high-throughput analysis of telomerase modulators with Telospot

Controlled and localized genetic manipulation in the brain

Mining gene sets for measuring similarities

Hardware/Software Coevolution of Genome Programs and Cellular Processors

Microfluidic Applications in Biology From Technologies to Systems Biology

Similarities and differences of polyadenylation signals in human and fly

Adaptive Distributed Algorithms for Power-Efficient Data Gathering in Sensor Networks

A first version of the Caenorhabditis elegans Promoterome

Tree-Based Pursuit

Scaling Laws for Correlated Data Gathering

Tree-Based Pursuit

Microfluidic Applications in Biology From Technologies to Systems Biology

A first version of the Caenorhabditis elegans Promoterome

Low- to high-throughput analysis of telomerase modulators with Telospot

Mining gene sets for measuring similarities

Hardware/Software Coevolution of Genome Programs and Cellular Processors

Similarities and differences of polyadenylation signals in human and fly

Scaling Laws for Correlated Data Gathering

Adaptive Distributed Algorithms for Power-Efficient Data Gathering in Sensor Networks

Controlled and localized genetic manipulation in the brain