Investigating the molecular basis of ligand binding to and activation of olfactory receptors in living cells
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Much information is conveyed to animals by the diverse molecules propagated in their environment. This information is transmitted and treated within the olfactory system to be utilized by the rest of the brain. In this process, the sensory flow arriving fr ...
Olfaction and the olfactory pathway is a good system to study sensory processing in general, mainly because of the simplified organization of the cells constituting the olfactory bulb, the anatomical structure responsible for early odor encoding and proces ...
The animal olfactory system represents the gold standard of olfactory biosensors with its capability to identify and discriminate thousands of odorant compounds. In order to mimic the performances of natural olfactory sensors it is necessary to develop met ...
Odor perception may be considered from different perspectives: the physicochemical properties of odorants and target surfaces of interest, the biological aspects of electing odorant molecules by odorant receptors and their related downstream cellular signa ...
The notion that long-term synaptic plasticity is generated by activity-induced molecular modifications is widely accepted. It is well established that neural cell adhesion molecule (NCAM) is one of the prominent modulators of synaptic plasticity. NCAM can ...
The animal olfactory system represents the gold standard of biosensors, due to its ability to identify and discriminate thousands of odorant compounds with very low thresholds. Using olfactory receptors (ORs) as sensing elements instead of chemical sensors ...
Optical imaging techniques offer powerful solutions to capture brain networks processing in animals, especially when activity is distributed in functionally distinct spatial domains. Despite the progress in imaging techniques, the standard analysis procedu ...
Despite the importance of trafficking for regulating G protein-coupled receptor signaling, for many members of the seven transmembrane helix protein family, such as odorant receptors, little is known about this process in live cells. Here, the complete lif ...
BACKGROUND: Odorant receptors (ORs) are thought to act in a combinatorial fashion, in which odor identity is encoded by the activation of a subset of ORs and the olfactory sensory neurons (OSNs) that express them. The extent to which a single OR contribute ...
Olfaction, the detection of odorous chemicals in the environment, is one of the oldest mammalian sensory systems and involves large number (up to 1000) of distinct G protein coupled olfactory receptors (OR). The chemical interaction of volatile molecules w ...