Variability of the pullout strength of cancellous bone screws with cement augmentation

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Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Martin Guillermo Mueller, Jeremy Pak Hei Wong

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyele ...

2020

MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections

Olaia Maria Naveiras Torres-Quiroga, Olivier Burri, Rita Sarkis, Nicolas Kunz, Vasco Ledebur de Antas de Campos, Josefine Catharina Pedersen Tratwal, Frédérica Schyrr, Chiheb Boussema, Shanti Rojas-Sutterlin, Daniel Naveed Tavakol

The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow marrow depending on skeletal location, age, and physiological condition. Mouse models and patients undergoing radio/chemotherapy or suffering acute BM failure endure rapi ...

2020

Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography

Julien Favre, Brigitte Jolles-Haeberli

Objective: To test whether subchondral bone mineral density (sBMD) and cartilage thickness (CTh) of femoral condyles are correlated in knees without and with severe medial femorotibial osteoarthritis (OA), using a subregional analysis with computerized tom ...

ELSEVIER SCI LTD2019

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SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

Johan Auwerx, Dongryeol Ryu, Olivier Staub, Lilia Noriega Lopez

SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...

2021

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Martin Guillermo Mueller, Jeremy Pak Hei Wong

2020

Sub-trabecular strain evolution in human trabecular bone

Goran Lovric, Alessandra Patera

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

NATURE RESEARCH2020

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

Matthias Lütolf, Olaia Maria Naveiras Torres-Quiroga, Aline Roch, Philipp Sebastian Lienemann, Stéphanie Elisabeth Metzger, Queralt Vallmajó Martín, Martin Ehrbar, Vincent Milleret, Manuel Koch, Panagiota Papageorgiou

The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mob ...

WILEY2020

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

Lakshmi Devi Chakkarapani

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...

2020

Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis

Josefine Catharina Pedersen Tratwal

Over the last decade, bone marrow (BM) adipose tissue (BMAT) has emerged as a distinct adipose depot with unique metabolic properties and effects both in homeostasis and in the progression of disease. We provide a first comprehensive review of existing an ...

EPFL2020

MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections

2020

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Erick Jorge Canales Rodriguez, Wenhao Jiang

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this intr ...

2020

Relationships between cartilage thickness and subchondral bone mineral density in non-osteoarthritic and severely osteoarthritic knees: In vivo concomitant 3D analysis using CT arthrography

Julien Favre, Brigitte Jolles-Haeberli

ELSEVIER SCI LTD2019

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Queralt Vallmajó Martín

The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...

EPFL2019

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