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Duocarmycins are a potent class of antitumor agents. Their activity arises by their covalent binding to adenine nucleobases of DNA. We use classical mol. dynamics and hybrid (QM/MM) Car-Parrinello mol. dynamics simulations to study non-covalent and covalen ...
Professor James E. Bailey was not only a world-renowned leader and pioneer in biochem. engineering but also a mentor to the many graduate students and postdoctoral researchers in his group. To provide non-"Bailey-ites" with an impression of Jay as a mentor ...
New 3-oxy substituted and 3,6-dioxydisubstituted 7-oxabicyclo[2.2.1]heptan-2-ones have been prepared. The regioselectivity of their Baeyer-Villiger oxidation has been determined and compared with that of other 7-oxabicyclo[2.2.1[heptan-2-one derivatives. I ...
When treated with BuLi and KOCMe3 for 2 h at 0 Deg in hexane, the unsatd. monoterpenic alc. isopulegol is simultaneously deprotonated at the hydroxy function and the allylic Me group. The metaloxy allylmetal species thus generated can be silylated, alkylat ...
For the group of endo-permutation modules of a finite p-group, there is a surjective reduction homomorphism from a complete discrete valuation ring of characteristic 0 to its residue field of characteristic p. We prove that this reduction map always has a ...
This paper provides an overview of the SWARM-BOTS project, a robotic project sponsored by the Future and Emerging Technologies program of the European Community (IST-2000-31010). The paper illustrates the robot hardware, and the results of experimental wor ...
This thesis work aimed to show the potentialities of the organometallic approach and, in particular, the organoalkali one, in Organic Synthesis (whose possibilities cannot be underestimated). A wide opening on the big landscape of possibilities has been re ...
The OH group in cyanohydrins RR1C(OH)CN [R = Me2CH, R1 = H; R = R1 = Me; RR1 = (CH2)4, (CH2)5] was protected with EtOCH:CH2 to give RR1C(CN)OCHMeOEt, which were then reduced by NaAlH2(OCH2CH2OMe)2 to RR1C(CHO)OCHMeOEt (I) (53-70%), which were hydrolyzed wi ...
Materials for use in controlled release of water sol. macromol. drugs, such as proteins and polysaccharides, were developed, i.e. (1) a material that would be phase compatible with the water sol. drug; (2) a material that would induce a reduced inflammator ...
