Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory
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Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...
Cambridge2023
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Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...
2022
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Episodic autobiographical memories are characterized by a spatial context and an affective component. But how do affective and spatial aspects interact? Does affect modulate the way we encode the spatial context of events? We investigated how one element o ...
NATL ACAD SCIENCES2022
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We present a new method for generating realistic and view-consistent images with fine geometry from 2D image collections. Our method proposes a hybrid explicitimplicit representation called OrthoPlanes, which encodes fine-grained 3D information in feature ...
Ieee Computer Soc2023
Attractive serial dependence occurs when perceptual decisions are attracted toward previous stimuli. This effect is mediated by spatial attention and is most likely to occur when similar stimuli are attended at nearby locations. Attention, however, also in ...
Rockville2023
Short-term synaptic plasticity and modulations of the presynaptic vesicle release rate are key components of many working memory models. At the same time, an increasing number of studies suggests a potential role of astrocytes in modulating higher cognitiv ...
PUBLIC LIBRARY SCIENCE2022
It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are promin ...
FRONTIERS MEDIA SA2022
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a genetic disease associated with an increased risk for schizophrenia and a specific cognitive profile. In this paper, we challenge the current view of spared verbal memory in 22q11.2DS by investigating v ...
2019
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Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term ...
2019
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The stress response facilitates survival through adaptation and is intimately related to cognitive processes. The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been sugges ...
