High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides

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Methods for the generation of large combinatorial macrocycle libraries

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water

Jérôme Waser, Durga Prasada Rao Hari, Romain Gaëtan Tessier, Abhaya Kumar Mishra

We report the functionalization of cysteine residues with lipophilic alkynes bearing a silyl group or an alkyl chain using amphiphilic ethynylbenziodoxolone reagents (EBXs). The reactions were carried out in buffer (pH 6 to 9), without organic co-solvent o ...

Wiley-VCH Verlag GmbH2021

Grafting of Alkali Metals on Fumed Silica for the Catalytic Dehydrogenation of Methanol to Formaldehyde

Oliver Kröcher, Alimohammad Bahmanpour, Christophe Jean Baranowski, Jack Brandon

Water free, non-oxidative catalytic dehydrogenation of methanol to formaldehyde is an important process for the formation of anhydrous, molecular formaldehyde (FA). Sodium or sodium-containing salts were shown to catalyze the reaction, but their reaction m ...

Wiley-VCH Verlag2021

A smart low molecular weight gelator for the triple detection of copper (II), mercury (II), and cyanide ions in water resources

Rosario Scopelliti

Novel supramolecular gelators based on quinoline-indolin-2-one structure were synthesized. These gelators formed stable organogels in a mixture of DMSO/H2O (1:1). The scanning electron microscopy (SEM), IR and NMR spectroscopies, and rheological measuremen ...

ELSEVIER2020

Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides

Christian Heinis, Van Manh Pham, Milan Bergeron-Brlek

DNA-encoded chemical library technologies enable the screening of large combinatorial libraries of chemically and structurally diverse molecules, including short cyclic peptides. A challenge in the combinatorial synthesis of cyclic peptides is the final st ...

2020

Influence of curing temperature on cement paste microstructure measured by H-1 NMR relaxometry

Karen Scrivener, Arnaud Charles Albert Muller

H-1 nuclear magnetic resonance (NMR) relaxometry, supported by X-Ray diffraction and thermogravimetric analysis, has been used to characterise microstructure of white cement pastes underwater cured at temperatures in the range 10 degrees C to 60 degrees C. ...

Pergamon-Elsevier Science Ltd2019

Water Redistribution-Microdiffusion in Cement Paste under Mechanical Loading Evidenced by H-1 NMR

Karen Scrivener, Pietro Lura

The mobility of water within the microstructure of hardened cement paste has been at the center of a long-lasting debate, motivated by the need to understand the fundamental mechanisms that play a role in drying, shrinkage, creep, and thermal expansion. Ou ...

2019

Application of Hypervalent Iodine Reagents for Novel Cysteine Labeling

Romain Gaëtan Tessier

Selective functionalization of peptides and proteins has always been a valuable tool for the study and manipulation of biological processes. In this context, cysteines are of particular interest. Their intrinsic high nucleophilicity makes these amino acids ...

EPFL2019

C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation

Jérôme Waser, Franck Le Vaillant, Marion Marie-Agnès Garreau

We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. ...

Wiley-VCH Verlag GmbH2019

Slowing the Kinetics of Alumina Sol-Gel Chemistry for Controlled Catalyst Overcoating and Improved Catalyst Stability and Selectivity

Jeremy Luterbacher, Yuan-Peng Du, Florent Emmanuel Héroguel

Catalyst overcoating is an emerging approach to engineer surface functionalities on supported metal catalyst and improve catalyst selectivity and durability. Alumina deposition on high surface area material by sol–gel chemistry is traditionally difficult t ...

2018

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