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Nanoparticles comprising a metal core surrounded by a monolayer for lymph node targeting

Related publications (31)

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...

EPFL2024

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Didier Trono, Priscilla Turelli, Sandra Eloise Kjeldsen, Evaristo Jose Planet Letschert, Filipe Amândio Brandão Sanches Vong Martins, Florian Huber, Cyril David Son-Tuyên Pulver, Olga Marie Louise Rosspopoff, Romain Forey, Joana Carlevaro Fita

Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc fin ...

2024

Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node

Daniel Molina Romero

Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...

EPFL2023

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Christian Heinis, Florence Pojer, Kelvin Ka Ching Lau, Cristina Diaz Perlas, Lluc Farrera Soler

A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price. ...

Nature Portfolio2023

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea

Alessio Mylonas, Yichen Wang, Jiaqi Chen

Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves c ...

AMER SOC CLINICAL INVESTIGATION INC2023

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Alexander Hooftman

Background Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory disease. For this reason, their activation state is governed by a multitude of factors, including the metabo ...

Karger2023

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Xiaoxu Li

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

EPFL2023

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Clara Bonnet

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

BMC2022

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Flavia Aurelia Shoko Hodel

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

EPFL2022

Nanoparticles comprising a metal core surrounded by a monolayer for lymph node targeting

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

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Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure