Direction of Arrival with One Microphone, a few LEGOs, and Non-Negative Matrix Factorization

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Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss

Nicolas Jean Philippe Guex

Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...

Oxford University Press2021

Transverse Noise, Decoherence, and Landau Damping in High-Energy Hadron Colliders

Sondre Vik Furuseth

High-energy hadron colliders are designed to generate particle collisions within specialized detectors. A higher number of collisions is achieved with high-quality beams of low transverse emittances, meaning a small transverse cross-section, and high inten ...

EPFL2021

Good Vibrations and Unknown Excitations

Dalia Salem Hassan Fahmy El Badawy

Inspired by the human ability to localize sounds, even with only one ear, as well as to recognize objects using active echolocation, we investigate the role of sound scattering and prior knowledge in regularizing ill-posed inverse problems in acoustics. In ...

EPFL2020

Dissecting self-voice perception: From bone conduction to robotically-induced self-other voice misattribution in healthy listeners

Pavo Orepic

Inspired by the prominent theory suggesting that auditory-verbal hallucinations (AVH) - the sensation of hearing voices without present speakers - arise as misattribution of inner speech towards external agents, my thesis revolved around self-voice percept ...

EPFL2020

Sparse and Parametric Modeling with Applications to Acoustics and Audio

Helena Peic Tukuljac

Recent advances in signal processing, machine learning and deep learning with sparse intrinsic structure of data have paved the path for solving inverse problems in acoustics and audio. The main task of this thesis was to bridge the gap between the powerfu ...

EPFL2020

Perception of Auditory Distance in Normal-Hearing and Moderate-to-Profound Hearing-Impaired Listeners

Hervé Lissek, Gilles André Courtois, Vincent Pierre Olivier Grimaldi

The auditory system allows the estimation of the distance to sound-emitting objects using multiple spatial cues. In virtual acoustics over headphones, a prerequisite to render auditory distance impression is sound externalization, which denotes the percept ...

2019

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...

2019

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Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss

Nicolas Jean Philippe Guex

Oxford University Press2021

Dissecting self-voice perception: From bone conduction to robotically-induced self-other voice misattribution in healthy listeners

Pavo Orepic

EPFL2020